What is the role of titin in active muscle?

Jenna A. Monroy, Krysta L. Powers, Leslie A. Gilmore, Theodore A. Uyeno, Stan L. Lindstedt, Kiisa C. Nishikawa

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Several properties of muscle defy explanation solely based on the sliding filament-swinging cross-bridge theory. Indeed, muscle behaves as though there is a dynamic "spring" within the sarcomeres. We propose a new "winding filament" mechanism for how titin acts, in conjunction with the cross-bridges, as a force-dependent spring. The addition of titin into active sarcomeres resolves many puzzling muscle characteristics.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalExercise and Sport Sciences Reviews
Issue number2
StatePublished - Apr 2012


  • Connectin
  • force depression
  • force enhancement
  • history dependence
  • sliding filament theory
  • thin filament rotation
  • titin-actin interactions

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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