What is the role of titin in active muscle?

Jenna A. Monroy; Krysta L. Powers; Leslie A. Gilmore; Theodore A. Uyeno; Stan L. Lindstedt; Kiisa C. Nishikawa

doi:10.1097/JES.0b013e31824580c6

What is the role of titin in active muscle?

Jenna A. Monroy, Krysta L. Powers, Leslie A. Gilmore, Theodore A. Uyeno, Stan L. Lindstedt, Kiisa C. Nishikawa

Biological Sciences

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Several properties of muscle defy explanation solely based on the sliding filament-swinging cross-bridge theory. Indeed, muscle behaves as though there is a dynamic "spring" within the sarcomeres. We propose a new "winding filament" mechanism for how titin acts, in conjunction with the cross-bridges, as a force-dependent spring. The addition of titin into active sarcomeres resolves many puzzling muscle characteristics.

Original language	English (US)
Pages (from-to)	73-78
Number of pages	6
Journal	Exercise and Sport Sciences Reviews
Volume	40
Issue number	2
DOIs	https://doi.org/10.1097/JES.0b013e31824580c6
State	Published - Apr 2012

Keywords

Connectin
force depression
force enhancement
history dependence
sliding filament theory
thin filament rotation
titin-actin interactions

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

Access to Document

10.1097/JES.0b013e31824580c6

Cite this

@article{0c25a62685384b6fa0202d70417d2b99,

title = "What is the role of titin in active muscle?",

abstract = "Several properties of muscle defy explanation solely based on the sliding filament-swinging cross-bridge theory. Indeed, muscle behaves as though there is a dynamic {"}spring{"} within the sarcomeres. We propose a new {"}winding filament{"} mechanism for how titin acts, in conjunction with the cross-bridges, as a force-dependent spring. The addition of titin into active sarcomeres resolves many puzzling muscle characteristics.",

keywords = "Connectin, force depression, force enhancement, history dependence, sliding filament theory, thin filament rotation, titin-actin interactions",

author = "Monroy, {Jenna A.} and Powers, {Krysta L.} and Gilmore, {Leslie A.} and Uyeno, {Theodore A.} and Lindstedt, {Stan L.} and Nishikawa, {Kiisa C.}",

year = "2012",

month = apr,

doi = "10.1097/JES.0b013e31824580c6",

language = "English (US)",

volume = "40",

pages = "73--78",

journal = "Exercise and Sport Sciences Reviews",

issn = "0091-6331",