Viral detection using an embedded piezoresistive microcantilever sensor

R. L. Gunter, W. G. Delinger, K. Manygoats, A. Kooser, T. L. Porter

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


The detection of aerosol-based vaccinia virus and solution-based vaccinia virus has been studied using a new type of microsensor design. In the embedded piezoresistive microcantilever (EPM) sensor, a tiny piezoresistive microcantilever is embedded or partially embedded into an active sensing material whose volumetric response to the presence of an analyte is recorded as a strain in the cantilever, and subsequent change in the resistance of the cantilever. In one set of experiments, a composite consisting of poly(ethylene oxide), or PEO, combined with vaccinia antibody was used as the active sensing material. In aerosol exposures, this sensor produced a distinct signal owing to vaccinia virus adsorption/incorporation. In addition, experiments using a piezoresistive microcantilever in direct contact with a pure antibody layer in solution were also performed to detect vaccinia virus in solution. Again, a clear and distinct analyte signals obtained.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalSensors and Actuators, A: Physical
Issue number3
StatePublished - Nov 1 2003


  • Embedded
  • Microcantilever
  • Piezoresistive
  • Vaccinia

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering


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