Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids

Katherine S. Lovejoy; Cynthia A. Corley; Emily K. Cope; Michael C. Valentine; Jeff G. Leid; Geraldine M. Purdy; John S. Wilkes; Andrew T. Koppisch; Rico E. Del Sesto

doi:10.1021/cg300969u

Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids

Katherine S. Lovejoy, Cynthia A. Corley, Emily K. Cope, Michael C. Valentine, Jeff G. Leid, Geraldine M. Purdy, John S. Wilkes, Andrew T. Koppisch, Rico E. Del Sesto

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A new strategy employs amorphous melts of active pharmaceutical agents, which are formed with metal chlorides, including ZnCl ₂, through speciation ambiguity. The Lewis acidic, bioinorganic ionic liquid formulations improve shelf life and water solubility and eliminate issues related to crystal polymorphism. This broad-ranging approach produces thermally robust chlorometallate preparations for use as lotions, antibiofilm agents, and in situations without refrigeration.

Original language	English (US)
Pages (from-to)	5357-5364
Number of pages	8
Journal	Crystal Growth and Design
Volume	12
Issue number	11
DOIs	https://doi.org/10.1021/cg300969u
State	Published - Nov 7 2012

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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10.1021/cg300969u

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abstract = "A new strategy employs amorphous melts of active pharmaceutical agents, which are formed with metal chlorides, including ZnCl 2, through speciation ambiguity. The Lewis acidic, bioinorganic ionic liquid formulations improve shelf life and water solubility and eliminate issues related to crystal polymorphism. This broad-ranging approach produces thermally robust chlorometallate preparations for use as lotions, antibiofilm agents, and in situations without refrigeration.",

author = "Lovejoy, {Katherine S.} and Corley, {Cynthia A.} and Cope, {Emily K.} and Valentine, {Michael C.} and Leid, {Jeff G.} and Purdy, {Geraldine M.} and Wilkes, {John S.} and Koppisch, {Andrew T.} and {Del Sesto}, {Rico E.}",

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AU - Lovejoy, Katherine S.

AU - Corley, Cynthia A.

AU - Cope, Emily K.

AU - Valentine, Michael C.

AU - Leid, Jeff G.

AU - Purdy, Geraldine M.

AU - Wilkes, John S.

AU - Koppisch, Andrew T.

AU - Del Sesto, Rico E.

PY - 2012/11/7

Y1 - 2012/11/7

N2 - A new strategy employs amorphous melts of active pharmaceutical agents, which are formed with metal chlorides, including ZnCl 2, through speciation ambiguity. The Lewis acidic, bioinorganic ionic liquid formulations improve shelf life and water solubility and eliminate issues related to crystal polymorphism. This broad-ranging approach produces thermally robust chlorometallate preparations for use as lotions, antibiofilm agents, and in situations without refrigeration.

AB - A new strategy employs amorphous melts of active pharmaceutical agents, which are formed with metal chlorides, including ZnCl 2, through speciation ambiguity. The Lewis acidic, bioinorganic ionic liquid formulations improve shelf life and water solubility and eliminate issues related to crystal polymorphism. This broad-ranging approach produces thermally robust chlorometallate preparations for use as lotions, antibiofilm agents, and in situations without refrigeration.

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Utilization of metal halide species ambiguity to develop amorphous, stabilized pharmaceutical agents as ionic liquids

Abstract

ASJC Scopus subject areas

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