Use of mechanistic models to integrate and analyze multiple proteomic datasets

Keyphrases

• Mechanistic Model 100%
• Epidermal Growth Factor Receptor Signaling 100%
• Proteomics Dataset 100%
• Epidermal Growth Factor Receptor 66%
• Protein-protein Interaction 33%
• Binding Partners 33%
• Well-defined 33%
• Binding Affinity 33%
• Specific Model 33%
• Receptor Signaling 33%
• Mass Action 33%
• Physicochemical Parameters 33%
• YES1 33%
• Protein Copy number 33%
• Network Properties 33%
• SHC1 33%
• Multiple Cell Lines 33%
• Mechanistic Computational Model 33%
• Grb2 33%
• Cell Signaling Networks 33%
• Specific Difference 33%
• Importance Ranking 33%
• Signaling Network 33%
• Relative Affinity 33%
• Low-affinity Interactions 33%
• Phosphotyrosine Binding Domains 33%
• Protein of Interest 33%
• SH3 Domain 33%
• Autophosphorylation 33%

Biochemistry, Genetics and Molecular Biology

• Proteomics 100%
• Epidermal Growth Factor Receptor 100%
• Eicosanoid Receptor 60%
• Signal Transduction 20%
• Protein-Protein Interaction 20%
• GRB2 20%
• Binding Affinity 20%
• Autophosphorylation 20%
• Mass Action 20%
• Phosphotyrosine-Binding Domain 20%
• Cell Membrane Potential 20%