TY - JOUR
T1 - Unraveling the role of the microbiome in chronic rhinosinusitis
AU - Psaltis, Alkis J.
AU - Mackenzie, Brett Wagner
AU - Cope, Emily K.
AU - Ramakrishnan, Vijay R.
N1 - Publisher Copyright:
© 2022 American Academy of Allergy, Asthma & Immunology
PY - 2022/5
Y1 - 2022/5
N2 - Chronic rhinosinusitis (CRS) is a complex, heterogenous condition that is likely associated with infectious and inflammatory causative factors. Renewed interest in the role that microbes play in this condition has stemmed from advancements in microbe identification and parallel research implicating the microbiome as having a role in other chronic inflammatory conditions. This clinical commentary provides a review of the current literature relevant to chronic rhinosinusitis. Particular focus is placed on factors specific to investigation of the sinonasal microbiome, evidence for the role of dysbiosis in the disease state, and influences that may affect the microbiome. Possible mechanisms of disease and therapeutic implications through microbial manipulation are also reviewed, as are deficiencies and limitations of the current body of research.
AB - Chronic rhinosinusitis (CRS) is a complex, heterogenous condition that is likely associated with infectious and inflammatory causative factors. Renewed interest in the role that microbes play in this condition has stemmed from advancements in microbe identification and parallel research implicating the microbiome as having a role in other chronic inflammatory conditions. This clinical commentary provides a review of the current literature relevant to chronic rhinosinusitis. Particular focus is placed on factors specific to investigation of the sinonasal microbiome, evidence for the role of dysbiosis in the disease state, and influences that may affect the microbiome. Possible mechanisms of disease and therapeutic implications through microbial manipulation are also reviewed, as are deficiencies and limitations of the current body of research.
KW - Microbiome
KW - chronic rhinosinusitis
KW - host-microbial interactions
KW - microbiome manipulation
KW - next-generation sequencing
KW - probiotic
KW - therapeutic intervention
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U2 - 10.1016/j.jaci.2022.02.022
DO - 10.1016/j.jaci.2022.02.022
M3 - Article
C2 - 35300985
AN - SCOPUS:85127332634
SN - 0091-6749
VL - 149
SP - 1513
EP - 1521
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 5
ER -