Unraveling the role of the microbiome in chronic rhinosinusitis

Alkis J. Psaltis, Brett Wagner Mackenzie, Emily K. Cope, Vijay R. Ramakrishnan

Research output: Contribution to journalArticlepeer-review


Chronic rhinosinusitis (CRS) is a complex, heterogenous condition that is likely associated with infectious and inflammatory causative factors. Renewed interest in the role that microbes play in this condition has stemmed from advancements in microbe identification and parallel research implicating the microbiome as having a role in other chronic inflammatory conditions. This clinical commentary provides a review of the current literature relevant to chronic rhinosinusitis. Particular focus is placed on factors specific to investigation of the sinonasal microbiome, evidence for the role of dysbiosis in the disease state, and influences that may affect the microbiome. Possible mechanisms of disease and therapeutic implications through microbial manipulation are also reviewed, as are deficiencies and limitations of the current body of research.

Original languageEnglish (US)
JournalJournal of Allergy and Clinical Immunology
StateAccepted/In press - 2022


  • chronic rhinosinusitis
  • host-microbial interactions
  • Microbiome
  • microbiome manipulation
  • next-generation sequencing
  • probiotic
  • therapeutic intervention

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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