Trivalent antigens for degranulation of mast cells

Richard G. Posner; Dianliang Geng; Seth Haymore; James Bogert; Israel Pecht; Arieh Licht; Paul B. Savage

doi:10.1021/ol071175h

Trivalent antigens for degranulation of mast cells

Richard G. Posner, Dianliang Geng, Seth Haymore, James Bogert, Israel Pecht, Arieh Licht, Paul B. Savage

Biological Sciences

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.

Original language	English (US)
Pages (from-to)	3551-3554
Number of pages	4
Journal	Organic Letters
Volume	9
Issue number	18
DOIs	https://doi.org/10.1021/ol071175h
State	Published - Aug 30 2007

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol071175h

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abstract = "Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.",

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AU - Posner, Richard G.

AU - Geng, Dianliang

AU - Haymore, Seth

AU - Bogert, James

AU - Pecht, Israel

AU - Licht, Arieh

AU - Savage, Paul B.

PY - 2007/8/30

Y1 - 2007/8/30

N2 - Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.

AB - Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.

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JO - Organic Letters

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Trivalent antigens for degranulation of mast cells

Abstract

ASJC Scopus subject areas

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