TY - JOUR
T1 - Towards translational epidemiology
T2 - Next-generation sequencing and phylogeography as epidemiological mainstays
AU - Hepp, Crystal M.
N1 - Funding Information:
Citation Hepp CM. 2019. Towards translational epidemiology: next-generation sequencing and phylogeography as epidemiological mainstays. mSystems 4:e00119-19. https://doi .org/10.1128/mSystems.00119-19. Copyright © 2019 Hepp. This is an open- access article distributed under the terms of the Creative Commons Attribution 4.0 International license. Address correspondence to CRYSTAL.HEPP@nau.edu. Conflict of Interest Disclosures: C.M.H. reports grants from the Arizona Biomedical Research Commission and the Pacific Southwest Regional Center of Excellence in Vector-Borne Diseases during the conduct of the study. mSystems® vol. 4, no. 3, is a special issue sponsored by Illumina.
Funding Information:
This work has been supported by the following funds awarded to Crystal Hepp: New Investigator Award from the Arizona Biomedical Research Center, start-up funds from the Arizona Technology Research and Initiative Fund, and a training grant through the Pacific Southwest Regional Center of Excellence for Vector-Borne Diseases funded by the U.S. Centers for Disease Control and Prevention (Cooperative Agreement 1U01CK000516).
Publisher Copyright:
© 2019 Hepp.
PY - 2019/5
Y1 - 2019/5
N2 - Next-generation sequencing, coupled with the development of user-friendly software, has achieved a level of accessibility that is revolutionizing the way we approach epidemiological investigations. We can sequence pathogen genomes and conduct phylogenetic analyses to assess transmission, identify from which country or city a pathogen originated, or which contaminated potluck item resulted in widespread foodborne illness. However, until recently, these types of studies have been rarities, limited to specific investigations usually conducted over the short term. Given the feasibility and realized public health benefits of ascertaining pathogen relationships, federal, state, and county agencies are building their sequencing capacities, either through acquisition of equipment or collaborative activities. In this perspective, I detail research projects that our group collaborates on with county and state public health agencies, where the objective is to identify pathogen source locations with the longer-term goal of implementing proactive interventions.
AB - Next-generation sequencing, coupled with the development of user-friendly software, has achieved a level of accessibility that is revolutionizing the way we approach epidemiological investigations. We can sequence pathogen genomes and conduct phylogenetic analyses to assess transmission, identify from which country or city a pathogen originated, or which contaminated potluck item resulted in widespread foodborne illness. However, until recently, these types of studies have been rarities, limited to specific investigations usually conducted over the short term. Given the feasibility and realized public health benefits of ascertaining pathogen relationships, federal, state, and county agencies are building their sequencing capacities, either through acquisition of equipment or collaborative activities. In this perspective, I detail research projects that our group collaborates on with county and state public health agencies, where the objective is to identify pathogen source locations with the longer-term goal of implementing proactive interventions.
KW - Public health
KW - Translational epidemiology
KW - Vector-borne diseases
KW - Zoonotic disease
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U2 - 10.1128/mSystems.00119-19
DO - 10.1128/mSystems.00119-19
M3 - Review article
AN - SCOPUS:85067387378
SN - 2379-5077
VL - 4
JO - mSystems
JF - mSystems
IS - 3
M1 - e00119-19
ER -