Total synthesis of polycavernoside A, a lethal toxin of the red alga Polycavernosa tsudai

Keyphrases

• Red Algae 100%
• Aglycon 100%
• Lethal Toxin 100%
• Total Synthesis 100%
• Methyl 33%
• Regioselectivity 33%
• Aldehydes 33%
• Cyclization 33%
• Stille Coupling 33%
• Macrolactone 33%
• Functional Groups 33%
• Linear Sequence 33%
• 3-hydroxypropionaldehyde 33%
• Lactones 33%
• Unsaturated Esters 33%
• Hiyama 33%
• Overall Yield 33%
• Silyl Enol Ethers 33%
• Yamaguchi Lactonization 33%
• Pantolactone 33%
• Vinyl Bromides 33%

Chemistry

• Primary Structure 100%
• Red 100%
• Yamaguchi Esterification 50%
• Silyl Ether 50%
• Nozaki-Hiyama Reaction 50%
• Lactone 50%