Titin: A tunable spring in active muscle

Kiisa Nishikawa

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Muscle has conventionally been viewed as a motor that converts chemical to kinetic energy in series with a passive spring, but new insights emerge when muscle is viewed as a composite material whose elastic elements are tuned by activation. New evidence demonstrates that calcium-dependent binding of N2A titin to actin increases titin stiffness in active skeletal muscles, which explains many long-standing enigmas of muscle physiology.

Original languageEnglish (US)
Pages (from-to)209-217
Number of pages9
Issue number3
StatePublished - May 2020


  • Muscle activation
  • Muscle mechanics
  • Shortening
  • Stiffness
  • Stretch

ASJC Scopus subject areas

  • Physiology


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