The importance of biofilms in chronic rhinosinusitis

Jeff G. Leid, Emily K. Cope, Stacy Parmenter, Mark E. Shirtliff, Scot Dowd, Randall Wolcott, Randall Basaraba Dvm, Darrell Hunsaker, James Palmer, Noam Cohen

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


There is mounting evidence that bacterial and possibly fungal biofilms play an important role in the etiology and persistence of Chronic Rhinosinusitis (CRS). CRS affects nearly 16-25% of the US population each year, with billions of dollars of annual healthcare expenditures dedicated to its treatment (Gliklich and Metson 1995). Unfortunately, the recalcitrant nature of the disease, which often exhibits a chronic relapsing course, significantly contributes to these healthcare costs. The reasons for the persistent nature of the disease are likely secondary to a number of underlying pathophysiologic mechanisms. Asthma, allergic rhinitis, Gram-positive and Gram-negative infections, aspirin-sensitive asthma, fungus, osteitis, nasal polyposis, superantigens, and other factors have been implicated as etiologies contributing to the development of CRS.

Original languageEnglish (US)
Title of host publicationBiofilm Infections
PublisherSpringer New York
Number of pages22
ISBN (Print)9781441960832
StatePublished - 2011

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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