The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View

Joao B. Xavier; Vincent B. Young; Joseph Skufca; Fiona Ginty; Traci Testerman; Alexander T. Pearson; Paul Macklin; Amir Mitchell; Ilya Shmulevich; Lei Xie; J. Gregory Caporaso; Keith A. Crandall; Nicole L. Simone; Filipa Godoy-Vitorino; Timothy J. Griffin; Katrine L. Whiteson; Heather H. Gustafson; Daniel J. Slade; Thomas M. Schmidt; Marina R.S. Walther-Antonio; Tal Korem; Bobbie Jo M. Webb-Robertson; Mark P. Styczynski; W. Evan Johnson; Christian Jobin; Jason M. Ridlon; Andrew Y. Koh; Michael Yu; Libusha Kelly; Jennifer A. Wargo

doi:10.1016/j.trecan.2020.01.004

The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View

Joao B. Xavier, Vincent B. Young, Joseph Skufca, Fiona Ginty, Traci Testerman, Alexander T. Pearson, Paul Macklin, Amir Mitchell, Ilya Shmulevich, Lei Xie, J. Gregory Caporaso, Keith A. Crandall, Nicole L. Simone, Filipa Godoy-Vitorino, Timothy J. Griffin, Katrine L. Whiteson, Heather H. Gustafson, Daniel J. Slade, Thomas M. Schmidt, Marina R.S. Walther-AntonioTal Korem, Bobbie Jo M. Webb-Robertson, Mark P. Styczynski, W. Evan Johnson, Christian Jobin, Jason M. Ridlon, Andrew Y. Koh, Michael Yu, Libusha Kelly, Jennifer A. Wargo

Informatics, Computing, and Cyber Systems, School of

Research output: Contribution to journal › Review article › peer-review

157 Scopus citations

Abstract

The collection of microbes that live in and on the human body – the human microbiome – can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell–cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology – a systems biology approach.

Original language	English (US)
Pages (from-to)	192-204
Number of pages	13
Journal	Trends in Cancer
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/j.trecan.2020.01.004
State	Published - Mar 2020

ASJC Scopus subject areas

Oncology
Cancer Research

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Xavier, J. B., Young, V. B., Skufca, J., Ginty, F., Testerman, T., Pearson, A. T., Macklin, P., Mitchell, A., Shmulevich, I., Xie, L., Caporaso, J. G., Crandall, K. A., Simone, N. L., Godoy-Vitorino, F., Griffin, T. J., Whiteson, K. L., Gustafson, H. H., Slade, D. J., Schmidt, T. M., ... Wargo, J. A. (2020). The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View. Trends in Cancer, 6(3), 192-204. https://doi.org/10.1016/j.trecan.2020.01.004

Xavier, JB, Young, VB, Skufca, J, Ginty, F, Testerman, T, Pearson, AT, Macklin, P, Mitchell, A, Shmulevich, I, Xie, L, Caporaso, JG, Crandall, KA, Simone, NL, Godoy-Vitorino, F, Griffin, TJ, Whiteson, KL, Gustafson, HH, Slade, DJ, Schmidt, TM, Walther-Antonio, MRS, Korem, T, Webb-Robertson, BJM, Styczynski, MP, Johnson, WE, Jobin, C, Ridlon, JM, Koh, AY, Yu, M, Kelly, L & Wargo, JA 2020, 'The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View', Trends in Cancer, vol. 6, no. 3, pp. 192-204. https://doi.org/10.1016/j.trecan.2020.01.004

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abstract = "The collection of microbes that live in and on the human body – the human microbiome – can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell–cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology – a systems biology approach.",

author = "Xavier, {Joao B.} and Young, {Vincent B.} and Joseph Skufca and Fiona Ginty and Traci Testerman and Pearson, {Alexander T.} and Paul Macklin and Amir Mitchell and Ilya Shmulevich and Lei Xie and Caporaso, {J. Gregory} and Crandall, {Keith A.} and Simone, {Nicole L.} and Filipa Godoy-Vitorino and Griffin, {Timothy J.} and Whiteson, {Katrine L.} and Gustafson, {Heather H.} and Slade, {Daniel J.} and Schmidt, {Thomas M.} and Walther-Antonio, {Marina R.S.} and Tal Korem and Webb-Robertson, {Bobbie Jo M.} and Styczynski, {Mark P.} and Johnson, {W. Evan} and Christian Jobin and Ridlon, {Jason M.} and Koh, {Andrew Y.} and Michael Yu and Libusha Kelly and Wargo, {Jennifer A.}",

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doi = "10.1016/j.trecan.2020.01.004",

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The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View

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