The bactericidal effect of silver nanoparticles

Jose Ruben Morones, Jose Luis Elechiguerra, Alejandra Camacho, Katherine Holt, Juan B. Kouri, Jose Tapia Ramírez, Miguel Jose Yacaman

Research output: Contribution to journalArticlepeer-review

4782 Scopus citations

Abstract

Nanotechnology is expected to open new avenues to fight and prevent disease using atomic scale tailoring of materials. Among the most promising nanomaterials with antibacterial properties are metallic nanoparticles, which exhibit increased chemical activity due to their large surface to volume ratios and crystallographic surface structure. The study of bactericidal nanomaterials is particularly timely considering the recent increase of new resistant strains of bacteria to the most potent antibiotics. This has promoted research in the well known activity of silver ions and silver-based compounds, including silver nanoparticles. The present work studies the effect of silver nanoparticles in the range of 1-100 nm on Gram-negative bacteria using high angle annular dark field (HAADF) scanning transmission electron microscopy (STEM). Our results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of ∼1-10 nm.

Original languageEnglish (US)
Pages (from-to)2346-2353
Number of pages8
JournalNanotechnology
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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