Synthesis of a functionalized benzofuran as a synthon for salvianolic acid C analogues as potential LDL Antioxidants

Gabriela López-Frías, Alejandro A. Camacho-Dávila, David Chávez-Flores, Gerardo Zaragoza-Galán, Víctor H. Ramos-Sánchez

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antioxidants for the prevention of cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)8654-8665
Number of pages12
JournalMolecules
Volume20
Issue number5
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Antioxidant
  • Benzofuran
  • Palladium

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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