Sustainable Synthesis of the Naturally Hypolipidemic Agent α-Asarone

Alejandro A. Camacho-Dávila; David Chávez-Flores; Gerardo Zaragoza-Galán; Víctor H. Ramos-Sánchez

doi:10.1080/00397911.2015.1041047

Sustainable Synthesis of the Naturally Hypolipidemic Agent α-Asarone

Alejandro A. Camacho-Dávila, David Chávez-Flores, Gerardo Zaragoza-Galán, Víctor H. Ramos-Sánchez

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented). A short and practical preparation of α-asarone was developed using the inexpensive methylisoeugenol as a starting material. The utilization of a sequence of tribromination, debromination, and copper-mediated aromatic substitution enabled the stereoselective formation of only the E-isomer of α-asarone in good yield.

Original language	English (US)
Pages (from-to)	1669-1674
Number of pages	6
Journal	Synthetic Communications
Volume	45
Issue number	14
DOIs	https://doi.org/10.1080/00397911.2015.1041047
State	Published - Jul 18 2015
Externally published	Yes

Keywords

atherosclerosis
cardiovascular
sustainable
α-Asarone

ASJC Scopus subject areas

Organic Chemistry

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10.1080/00397911.2015.1041047

Cite this

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abstract = "(Chemical Equation Presented). A short and practical preparation of α-asarone was developed using the inexpensive methylisoeugenol as a starting material. The utilization of a sequence of tribromination, debromination, and copper-mediated aromatic substitution enabled the stereoselective formation of only the E-isomer of α-asarone in good yield.",

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AU - Camacho-Dávila, Alejandro A.

AU - Chávez-Flores, David

AU - Zaragoza-Galán, Gerardo

AU - Ramos-Sánchez, Víctor H.

PY - 2015/7/18

Y1 - 2015/7/18

N2 - (Chemical Equation Presented). A short and practical preparation of α-asarone was developed using the inexpensive methylisoeugenol as a starting material. The utilization of a sequence of tribromination, debromination, and copper-mediated aromatic substitution enabled the stereoselective formation of only the E-isomer of α-asarone in good yield.

AB - (Chemical Equation Presented). A short and practical preparation of α-asarone was developed using the inexpensive methylisoeugenol as a starting material. The utilization of a sequence of tribromination, debromination, and copper-mediated aromatic substitution enabled the stereoselective formation of only the E-isomer of α-asarone in good yield.

KW - atherosclerosis

KW - cardiovascular

KW - sustainable

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Sustainable Synthesis of the Naturally Hypolipidemic Agent α-Asarone

Abstract

Keywords

ASJC Scopus subject areas

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