Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells

Daniela A. Geraldo; Esteban F. Duran-Lara; Daniel Aguayo; Raul E. Cachau; Jaime Tapia; Rodrigo Esparza; Miguel J. Yacaman; Fernando Danilo Gonzalez-Nilo; Leonardo S. Santos

doi:10.1007/s00216-011-4756-2

Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells

Daniela A. Geraldo, Esteban F. Duran-Lara, Daniel Aguayo, Raul E. Cachau, Jaime Tapia, Rodrigo Esparza, Miguel J. Yacaman, Fernando Danilo Gonzalez-Nilo, Leonardo S. Santos

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.

Original language	English (US)
Pages (from-to)	483-492
Number of pages	10
Journal	Analytical and Bioanalytical Chemistry
Volume	400
Issue number	2
DOIs	https://doi.org/10.1007/s00216-011-4756-2
State	Published - Apr 2011
Externally published	Yes

Keywords

Gastric cancer cells
Molecular dynamics (MD) simulations
PAMAM dendrimers
Quantum dots
Supramolecular complexes
Transmission electron microscopy (TEM)

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1007/s00216-011-4756-2

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Geraldo, D. A., Duran-Lara, E. F., Aguayo, D., Cachau, R. E., Tapia, J., Esparza, R., Yacaman, M. J., Gonzalez-Nilo, F. D., & Santos, L. S. (2011). Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells. Analytical and Bioanalytical Chemistry, 400(2), 483-492. https://doi.org/10.1007/s00216-011-4756-2

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title = "Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells",

abstract = "Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.",

keywords = "Gastric cancer cells, Molecular dynamics (MD) simulations, PAMAM dendrimers, Quantum dots, Supramolecular complexes, Transmission electron microscopy (TEM)",

author = "Geraldo, {Daniela A.} and Duran-Lara, {Esteban F.} and Daniel Aguayo and Cachau, {Raul E.} and Jaime Tapia and Rodrigo Esparza and Yacaman, {Miguel J.} and Gonzalez-Nilo, {Fernando Danilo} and Santos, {Leonardo S.}",

note = "Funding Information: Acknowledgements D.A.G. and L.S.S. thank FONDECYT (Postdoctoral Grant 3100037), Proyecto Anillo Cient{\'i}fico ACT/24 (F.D.G. N.), and University of Texas at San Antonio (M.J.Y.) for supporting the research activity. This work has been funded in part with funds from the NCI-NIH (Contract No. HHSN261200800001E). The contents of this publication do not necessarily reflect the views or policies of the DHHS, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.",

year = "2011",

month = apr,

doi = "10.1007/s00216-011-4756-2",

language = "English (US)",

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AU - Geraldo, Daniela A.

AU - Duran-Lara, Esteban F.

AU - Aguayo, Daniel

AU - Cachau, Raul E.

AU - Tapia, Jaime

AU - Esparza, Rodrigo

AU - Yacaman, Miguel J.

AU - Gonzalez-Nilo, Fernando Danilo

AU - Santos, Leonardo S.

N1 - Funding Information: Acknowledgements D.A.G. and L.S.S. thank FONDECYT (Postdoctoral Grant 3100037), Proyecto Anillo Científico ACT/24 (F.D.G. N.), and University of Texas at San Antonio (M.J.Y.) for supporting the research activity. This work has been funded in part with funds from the NCI-NIH (Contract No. HHSN261200800001E). The contents of this publication do not necessarily reflect the views or policies of the DHHS, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

PY - 2011/4

Y1 - 2011/4

N2 - Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.

AB - Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.

KW - Gastric cancer cells

KW - Molecular dynamics (MD) simulations

KW - PAMAM dendrimers

KW - Quantum dots

KW - Supramolecular complexes

KW - Transmission electron microscopy (TEM)

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ER -

Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells

Abstract

Keywords

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