Substrate effects on interactions of lipid bilayer assemblies with bound nanoparticles

Matthew P. Goertz; Nikita Goyal; Bruce C. Bunker; Gabriel A. Montaño

doi:10.1016/j.jcis.2011.02.063

Substrate effects on interactions of lipid bilayer assemblies with bound nanoparticles

Matthew P. Goertz, Nikita Goyal, Bruce C. Bunker, Gabriel A. Montaño

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Understanding the interactions of nanoparticles with lipid membranes is crucial in establishing the mechanisms that govern assembly of membrane-based nanocomposites, nanotoxicology, and biomimetic inspired self-assembly. In this study, we explore binding of charged nanoparticles to lipid bilayers, both as liposomes and substrate supported assemblies. We find that the presence of a solid-support, regardless of curvature, eliminates the ability of zwitterionic fluid phase lipids to bind charged nanoparticles.

Original language	English (US)
Pages (from-to)	635-638
Number of pages	4
Journal	Journal of Colloid and Interface Science
Volume	358
Issue number	2
DOIs	https://doi.org/10.1016/j.jcis.2011.02.063
State	Published - Jun 15 2011
Externally published	Yes

Keywords

Biosensors
Lipid bilayer
Nanoparticles
Self-assembly

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Surfaces, Coatings and Films
Colloid and Surface Chemistry

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10.1016/j.jcis.2011.02.063

Cite this

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title = "Substrate effects on interactions of lipid bilayer assemblies with bound nanoparticles",

abstract = "Understanding the interactions of nanoparticles with lipid membranes is crucial in establishing the mechanisms that govern assembly of membrane-based nanocomposites, nanotoxicology, and biomimetic inspired self-assembly. In this study, we explore binding of charged nanoparticles to lipid bilayers, both as liposomes and substrate supported assemblies. We find that the presence of a solid-support, regardless of curvature, eliminates the ability of zwitterionic fluid phase lipids to bind charged nanoparticles.",

keywords = "Biosensors, Lipid bilayer, Nanoparticles, Self-assembly",

author = "Goertz, \{Matthew P.\} and Nikita Goyal and Bunker, \{Bruce C.\} and Monta{\~n}o, \{Gabriel A.\}",

note = "Funding Information: This work was performed, in part, at the Center for Integrated Nanotechnologies, a U.S. Department of Energy, Office of Basic Energy Sciences user facility. Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a Lockheed-Martin Company, for the U S Department of Energy under Contract No. DE-AC04-94AL85000. Los Alamos National Laboratory, an affirmative action equal opportunity employer, is operated by Los Alamos National Security, LLC, for the National Nuclear Security Administration of the U.S. Department of Energy under contract DE-AC52-06NA25396. ",

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day = "15",

doi = "10.1016/j.jcis.2011.02.063",

language = "English (US)",

volume = "358",

pages = "635--638",

journal = "Journal of Colloid and Interface Science",

issn = "0021-9797",

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T1 - Substrate effects on interactions of lipid bilayer assemblies with bound nanoparticles

AU - Goertz, Matthew P.

AU - Goyal, Nikita

AU - Bunker, Bruce C.

AU - Montaño, Gabriel A.

N1 - Funding Information: This work was performed, in part, at the Center for Integrated Nanotechnologies, a U.S. Department of Energy, Office of Basic Energy Sciences user facility. Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a Lockheed-Martin Company, for the U S Department of Energy under Contract No. DE-AC04-94AL85000. Los Alamos National Laboratory, an affirmative action equal opportunity employer, is operated by Los Alamos National Security, LLC, for the National Nuclear Security Administration of the U.S. Department of Energy under contract DE-AC52-06NA25396.

PY - 2011/6/15

Y1 - 2011/6/15

N2 - Understanding the interactions of nanoparticles with lipid membranes is crucial in establishing the mechanisms that govern assembly of membrane-based nanocomposites, nanotoxicology, and biomimetic inspired self-assembly. In this study, we explore binding of charged nanoparticles to lipid bilayers, both as liposomes and substrate supported assemblies. We find that the presence of a solid-support, regardless of curvature, eliminates the ability of zwitterionic fluid phase lipids to bind charged nanoparticles.

AB - Understanding the interactions of nanoparticles with lipid membranes is crucial in establishing the mechanisms that govern assembly of membrane-based nanocomposites, nanotoxicology, and biomimetic inspired self-assembly. In this study, we explore binding of charged nanoparticles to lipid bilayers, both as liposomes and substrate supported assemblies. We find that the presence of a solid-support, regardless of curvature, eliminates the ability of zwitterionic fluid phase lipids to bind charged nanoparticles.

KW - Biosensors

KW - Lipid bilayer

KW - Nanoparticles

KW - Self-assembly

UR - https://www.scopus.com/pages/publications/79955109767

UR - https://www.scopus.com/inward/citedby.url?scp=79955109767&partnerID=8YFLogxK

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DO - 10.1016/j.jcis.2011.02.063

M3 - Article

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AN - SCOPUS:79955109767

SN - 0021-9797

VL - 358

SP - 635

EP - 638

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

IS - 2

ER -

Substrate effects on interactions of lipid bilayer assemblies with bound nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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