Substrate effects on interactions of lipid bilayer assemblies with bound nanoparticles

Matthew P. Goertz, Nikita Goyal, Bruce C. Bunker, Gabriel A. Montaño

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Understanding the interactions of nanoparticles with lipid membranes is crucial in establishing the mechanisms that govern assembly of membrane-based nanocomposites, nanotoxicology, and biomimetic inspired self-assembly. In this study, we explore binding of charged nanoparticles to lipid bilayers, both as liposomes and substrate supported assemblies. We find that the presence of a solid-support, regardless of curvature, eliminates the ability of zwitterionic fluid phase lipids to bind charged nanoparticles.

Original languageEnglish (US)
Pages (from-to)635-638
Number of pages4
JournalJournal of Colloid and Interface Science
Issue number2
StatePublished - Jun 15 2011
Externally publishedYes


  • Biosensors
  • Lipid bilayer
  • Nanoparticles
  • Self-assembly

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry


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