Substrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pump

Rungtip Chuanchuen; Takeshi Murata; Naomasa Gotoh; Herbert P. Schweizer

doi:10.1128/AAC.49.5.2133-2136.2005

Substrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pump

Rungtip Chuanchuen
, Takeshi Murata
, Naomasa Gotoh
, Herbert P. Schweizer

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

MexJK requires OprM for erythromycin efflux but not for triclosan efflux. Deletion of 15 OprM family outer membrane proteins (OMPs) revealed that only the TolC homolog OpmH functions with MexJK for triclosan efflux. This is the first report of natural utilization of multiple OMPs by a given resistance nodulation cell division transporter/membrane fusion protein pair.

Original language	English (US)
Pages (from-to)	2133-2136
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
Issue number	5
DOIs	https://doi.org/10.1128/AAC.49.5.2133-2136.2005
State	Published - May 2005
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Substrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pump",

abstract = "MexJK requires OprM for erythromycin efflux but not for triclosan efflux. Deletion of 15 OprM family outer membrane proteins (OMPs) revealed that only the TolC homolog OpmH functions with MexJK for triclosan efflux. This is the first report of natural utilization of multiple OMPs by a given resistance nodulation cell division transporter/membrane fusion protein pair.",

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T1 - Substrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pump

AU - Chuanchuen, Rungtip

AU - Murata, Takeshi

AU - Gotoh, Naomasa

AU - Schweizer, Herbert P.

PY - 2005/5

Y1 - 2005/5

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AB - MexJK requires OprM for erythromycin efflux but not for triclosan efflux. Deletion of 15 OprM family outer membrane proteins (OMPs) revealed that only the TolC homolog OpmH functions with MexJK for triclosan efflux. This is the first report of natural utilization of multiple OMPs by a given resistance nodulation cell division transporter/membrane fusion protein pair.

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U2 - 10.1128/AAC.49.5.2133-2136.2005

DO - 10.1128/AAC.49.5.2133-2136.2005

M3 - Article

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AN - SCOPUS:18244370493

SN - 0066-4804

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JO - Antimicrobial Agents and Chemotherapy

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IS - 5

ER -

Substrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pump

Abstract

ASJC Scopus subject areas

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