Substrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pump

Rungtip Chuanchuen, Takeshi Murata, Naomasa Gotoh, Herbert P. Schweizer

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

MexJK requires OprM for erythromycin efflux but not for triclosan efflux. Deletion of 15 OprM family outer membrane proteins (OMPs) revealed that only the TolC homolog OpmH functions with MexJK for triclosan efflux. This is the first report of natural utilization of multiple OMPs by a given resistance nodulation cell division transporter/membrane fusion protein pair.

Original languageEnglish (US)
Pages (from-to)2133-2136
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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