@article{c3df6a9248b74fe9a53fd156a9ba7b93,
title = "Staphylococcus aureus and the ecology of the nasal microbiome",
abstract = "The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.",
author = "Liu, {Cindy M.} and Price, {Lance B.} and Hungate, {Bruce A.} and Abraham, {Alison G.} and Larsen, {Lisbeth A.} and Kaare Christensen and Marc Stegger and Robert Skov and Andersen, {Paal Skytt}",
note = "Funding Information: For this work was provided by NIH (1R15DE021194-01) to CM.Land L.B.P. and NIH (Al 101371-02) to L.B.P., R.S., and P.S.A. The Danish Twin Registry is supported by a grant from the National Program for Research Infrastructure 2007 from the Danish Agency for Science Technology and Innovation. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the funding agency. Publisher Copyright: {\textcopyright} 2015 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).",
year = "2015",
month = jun,
doi = "10.1126/sciadv.1400216",
language = "English (US)",
volume = "1",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "5",
}