Silver nanocluster aptamers: In situ generation of intrinsically fluorescent recognition ligands for protein detection

Jaswinder Sharma; Hsin Chih Yeh; Hyojong Yoo; James H. Werner; Jennifer S. Martinez

doi:10.1039/c0cc03711g

Silver nanocluster aptamers: In situ generation of intrinsically fluorescent recognition ligands for protein detection

Jaswinder Sharma, Hsin Chih Yeh, Hyojong Yoo, James H. Werner, Jennifer S. Martinez

Research output: Contribution to journal › Article › peer-review

242 Scopus citations

Abstract

We have synthesized an intrinsically fluorescent recognition ligand that combines the high fluorescence quantum yield (>50%) of oligonucleotide templated AgNCs with the specificity and strong binding affinity of DNA aptamers for their target proteins, to develop a new strategy for detection of specific proteins.

Original language	English (US)
Pages (from-to)	2294-2296
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	8
DOIs	https://doi.org/10.1039/c0cc03711g
State	Published - Feb 7 2011
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Silver nanocluster aptamers: In situ generation of intrinsically fluorescent recognition ligands for protein detection",

abstract = "We have synthesized an intrinsically fluorescent recognition ligand that combines the high fluorescence quantum yield (>50%) of oligonucleotide templated AgNCs with the specificity and strong binding affinity of DNA aptamers for their target proteins, to develop a new strategy for detection of specific proteins.",

author = "Jaswinder Sharma and Yeh, {Hsin Chih} and Hyojong Yoo and Werner, {James H.} and Martinez, {Jennifer S.}",

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doi = "10.1039/c0cc03711g",

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AU - Sharma, Jaswinder

AU - Yeh, Hsin Chih

AU - Yoo, Hyojong

AU - Werner, James H.

AU - Martinez, Jennifer S.

PY - 2011/2/7

Y1 - 2011/2/7

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AB - We have synthesized an intrinsically fluorescent recognition ligand that combines the high fluorescence quantum yield (>50%) of oligonucleotide templated AgNCs with the specificity and strong binding affinity of DNA aptamers for their target proteins, to develop a new strategy for detection of specific proteins.

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JO - Chemical Communications

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Silver nanocluster aptamers: In situ generation of intrinsically fluorescent recognition ligands for protein detection

Abstract

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