Serum biomarkers for traumatic brain injury

Miriam D. Neher, Chesleigh N. Keene, Megan C. Rich, Hunter B. Moore, Philip F. Stahel

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

There is a lack of reliable serumbiomarkers for routine use in the diagnostic workup of people with traumatic brain injury. Multiple biomediators and biomarkers have been described in the pertinent literature in recent years; however, only a few candidate molecules have been associated with high sensitivity and high specificity for risk stratification and outcome prediction after traumatic brain injury. This review was designed to provide an overview of the state of the art regarding established serum biomarkers in the field and to outline future directions of investigation.

Original languageEnglish (US)
Pages (from-to)248-255
Number of pages8
JournalSouthern Medical Journal
Volume107
Issue number4
DOIs
StatePublished - Apr 2014
Externally publishedYes

Keywords

  • Astroglial injury
  • Axonal injury
  • Biomarkers
  • Neuronal injury
  • Outcome prediction
  • Risk stratification
  • Traumatic brain injury

ASJC Scopus subject areas

  • Medicine(all)

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