Scaling mitochondrial volume in heart to body mass

Hans Hoppeler; Stan L. Lindstedt; Helgard Claassen; C. Richard Taylor; Odile Mathieu; Ewald R. Weibel

doi:10.1016/0034-5687(84)90018-5

Scaling mitochondrial volume in heart to body mass

Hans Hoppeler, Stan L. Lindstedt, Helgard Claassen, C. Richard Taylor, Odile Mathieu, Ewald R. Weibel

Biological Sciences

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The heart mass was measured and the volume density of mitochondria, V_v(mt,f), morphometrically estimated in 11 mammalian species ranging from shrew (3 g) to cattle (920 kg). The mass or the volume of the heart muscle (Vh) was found to scale as Mb^0.970 whereas V_v(mt,f) scaled as Mb^-0.044. Hence, the total volume of mitochondria in heart, V(mt), scaled as Mb^0.927 (V(mt)= V_V(mt,f) × Vh). The volume of heart mitochondria was found to scale disproportionately to V̇_O2 max (Mb^0.75) but in proportion to resting cardiac work rate (Mb^0.9).

Original language	English (US)
Pages (from-to)	131-137
Number of pages	7
Journal	Respiration Physiology
Volume	55
Issue number	2
DOIs	https://doi.org/10.1016/0034-5687(84)90018-5
State	Published - Feb 1984

Keywords

Allometric relation
Cardiac muscle
Cat
Cattle
Coyote
Dog
Fox
Heart mass
Heart size
Horse
Maximal oxygen consumption
Mitochondrion
Myocardium
Rat
Shrew
Skeletal muscle
Wolf
Woodmouse

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

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10.1016/0034-5687(84)90018-5

Cite this

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title = "Scaling mitochondrial volume in heart to body mass",

abstract = "The heart mass was measured and the volume density of mitochondria, Vv(mt,f), morphometrically estimated in 11 mammalian species ranging from shrew (3 g) to cattle (920 kg). The mass or the volume of the heart muscle (Vh) was found to scale as Mb0.970 whereas Vv(mt,f) scaled as Mb-0.044. Hence, the total volume of mitochondria in heart, V(mt), scaled as Mb0.927 (V(mt)= VV(mt,f) × Vh). The volume of heart mitochondria was found to scale disproportionately to {\.V}O2 max (Mb0.75) but in proportion to resting cardiac work rate (Mb0.9).",

keywords = "Allometric relation, Cardiac muscle, Cat, Cattle, Coyote, Dog, Fox, Heart mass, Heart size, Horse, Maximal oxygen consumption, Mitochondrion, Myocardium, Rat, Shrew, Skeletal muscle, Wolf, Woodmouse",

author = "Hans Hoppeler and Lindstedt, {Stan L.} and Helgard Claassen and Taylor, {C. Richard} and Odile Mathieu and Weibel, {Ewald R.}",

note = "Funding Information: This work was supported by Swiss National Science Foundation Grant No. 3.332.78.",

year = "1984",

month = feb,

doi = "10.1016/0034-5687(84)90018-5",

language = "English (US)",

volume = "55",

pages = "131--137",

journal = "Respiration Physiology",

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T1 - Scaling mitochondrial volume in heart to body mass

AU - Hoppeler, Hans

AU - Lindstedt, Stan L.

AU - Claassen, Helgard

AU - Taylor, C. Richard

AU - Mathieu, Odile

AU - Weibel, Ewald R.

N1 - Funding Information: This work was supported by Swiss National Science Foundation Grant No. 3.332.78.

PY - 1984/2

Y1 - 1984/2

N2 - The heart mass was measured and the volume density of mitochondria, Vv(mt,f), morphometrically estimated in 11 mammalian species ranging from shrew (3 g) to cattle (920 kg). The mass or the volume of the heart muscle (Vh) was found to scale as Mb0.970 whereas Vv(mt,f) scaled as Mb-0.044. Hence, the total volume of mitochondria in heart, V(mt), scaled as Mb0.927 (V(mt)= VV(mt,f) × Vh). The volume of heart mitochondria was found to scale disproportionately to V̇O2 max (Mb0.75) but in proportion to resting cardiac work rate (Mb0.9).

AB - The heart mass was measured and the volume density of mitochondria, Vv(mt,f), morphometrically estimated in 11 mammalian species ranging from shrew (3 g) to cattle (920 kg). The mass or the volume of the heart muscle (Vh) was found to scale as Mb0.970 whereas Vv(mt,f) scaled as Mb-0.044. Hence, the total volume of mitochondria in heart, V(mt), scaled as Mb0.927 (V(mt)= VV(mt,f) × Vh). The volume of heart mitochondria was found to scale disproportionately to V̇O2 max (Mb0.75) but in proportion to resting cardiac work rate (Mb0.9).

KW - Allometric relation

KW - Cardiac muscle

KW - Cat

KW - Cattle

KW - Coyote

KW - Dog

KW - Fox

KW - Heart mass

KW - Heart size

KW - Horse

KW - Maximal oxygen consumption

KW - Mitochondrion

KW - Myocardium

KW - Rat

KW - Shrew

KW - Skeletal muscle

KW - Wolf

KW - Woodmouse

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SN - 0034-5687

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JO - Respiration Physiology

JF - Respiration Physiology

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ER -

Scaling mitochondrial volume in heart to body mass

Abstract

Keywords

ASJC Scopus subject areas

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