Uplift of the Eastern Cordillera in the northern Andes has been linked to orographic climate change and genesis of South America's largest river systems. The timing of initial uplift remains poorly constrained, with most estimates ranging from ca. 60 to ca. 5 Ma. New detrital zircon U-Pb ages from proximal fill of the Llanos foreland basin in Colombia reveal a pronounced mid-Cenozoic shift in provenance from an Amazonian craton source to an Andean fold-thrust belt source. This shift corresponds with changes in detrital zircon (U-Th)/He ages, a conglomeratic unroofing sequence, and a sharp increase in foredeep accumulation rates. These nearly simultaneous changes in zircon age spectra, clast compositions, and sediment accumulation are attributable to latest Oligocene uplift of the eastern flank of the Eastern Cordillera. The timing relationships suggest an early activation of the frontal thrust system, implying a long-term (up to 25 m.y.) cessation of orogenic wedge advance, potentially driven by structural inheritance and/or climate change.
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