Quorum-sensing signal synthesis by the Yersinia pestis acyl-homoserine lactone synthase YspI

J. Paul Kirwan, Ty A. Gould, Herbert P. Schweizer, Scott W. Bearden, Robert C. Murphy, Mair E.A. Churchill

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The acyl-homoserine lactone molecular species (AHLs) produced by the Yersinia pestis AHL synthase YspI were identified by biochemical and physical/chemical techniques. Bioassays of extracts from culture supernatants of the recombinant YspI and wild-type Yersinia pestis showed similar profiles of AHLs. Analysis by liquid chromatography-mass spectrometry revealed that the predominant AHLs were N-3-oxooctanoyl-L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lactone.

Original languageEnglish (US)
Pages (from-to)784-788
Number of pages5
JournalJournal of Bacteriology
Volume188
Issue number2
DOIs
StatePublished - Jan 2006
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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