Pseudomonas aeruginosa: Arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies

Mohamed E. El Zowalaty, Asmaa A. Al Thani, Thomas J. Webster, Ahmed E. El Zowalaty, Herbert P. Schweizer, Gheyath K. Nasrallah, Hany E. Marei, Hossam M. Ashour

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations

Abstract

Antimicrobial resistance is one of the most serious public health issues facing humans since the discovery of antimicrobial agents. The frequent, prolonged, and uncontrolled use of antimicrobial agents are major factors in the emergence of antimicrobial-resistant bacterial strains, including multidrug-resistant variants. Pseudomonas aeruginosa is a leading cause of nosocomial infections. The abundant data on the increased resistance to antipseudomonal agents support the need for global action. There is a paucity of new classes of antibiotics active against P. aeruginosa. Here, we discuss recent antibacterial resistance profiles and mechanisms of resistance by P. aeruginosa. We also review future potential methods for controlling antibiotic-resistant bacteria, such as phage therapy, nanotechnology and antipseudomonal vaccines.

Original languageEnglish (US)
Pages (from-to)1683-1706
Number of pages24
JournalFuture Microbiology
Volume10
Issue number10
DOIs
StatePublished - Oct 2015
Externally publishedYes

Keywords

  • antibiotics
  • antimicrobial
  • carbapenemases
  • decoys
  • efflux
  • gold
  • impermeability
  • mechanisms
  • multidrug
  • nanoantimicrobial
  • nanoparticles
  • nanostars
  • pandrug
  • phage therapy
  • polymersomes
  • Pseudomonas aeruginosa
  • pumps
  • resistance
  • vaccines
  • vecoys
  • virus
  • β-lactamases

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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