Procedures for the Synthesis and Capping of Metal Nanoparticles

Claudia Gutiérrez-Wing, J. Jesús Velázquez-Salazar, Miguel José-Yacamán

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


The increasing impact of metallic nanoparticles on life sciences has stimulated the development of new techniques and multiple improvements to the existing methods of manufacturing nanoparticles with tailored properties. Nanoparticles can be synthesized through a variety of physical and chemical methods. The choice of preparation procedure will depend on the physical and chemical characteristics required in the final product, such as size, dispersion, chemical miscibility, and optical properties, among others. Here we review basic practical procedures used for the preparation of protected and unprotected metallic nanoparticles and describe a number of experimental procedures based on colloidal chemistry methods. These include gold nanoparticle synthesis by reduction with trisodium citrate, ascorbic acid, or sugars in aqueous phase and nanoparticle passivation with alkanethiols, CTAB, or BSA. We also describe microwave-assisted synthesis, nanoparticle synthesis in ethylene glycol, and template-assisted synthesis with dendrimers, and, briefly, how to control nanoparticle shape (star-shaped and branched nanoparticles).

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages18
StatePublished - 2020
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Colloidal particles
  • Nanomaterials
  • Nanoparticles
  • Nanostructures synthesis
  • Nanotechnology
  • Passivated particles

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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