Pilot immunization of mice infected with an equine strain of Corynebacterium pseudotuberculosis

Jennifer K. Gorman, Mourad Gabriel, N. James MacLachlan, Nathan C. Nieto, Janet E. Foley, Sharon J. Spier

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


This pilot study evaluated protection of an equine autogenous bacterin-toxoid vaccine against Corynebacterium pseudotuberculosis infection. Twenty-four BALB/c mice were inoculated with two doses of bacterin-toxoid vaccine or two injections of a placebo. Clinical, microbiologic, and pathologic outcomes were assessed after intradermal infection with one of two equine-origin C. pseudotuberculosis strains. Mice receiving bacterin-toxoid from fast-growing C. pseudotuberculosis showed significant protection from challenge infection, as evidenced by a higher survival rate, fewer gross and histopathologic lesions, and lower bacterial levels on culture. Successful protection via a vaccine against equine internal abscesses might provide supplementary management options against an important, potentially fatal disease.

Original languageEnglish (US)
JournalVeterinary Therapeutics
Issue number1
StatePublished - 2010

ASJC Scopus subject areas

  • General Veterinary


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