Phylogeography of Francisella tularensis ssp. holarctica in France

A. J. Vogler; D. N. Birdsell; J. Lee; J. Vaissaire; C. L. Doujet; M. Lapalus; D. M. Wagner; P. Keim

doi:10.1111/j.1472-765X.2010.02977.x

Phylogeography of Francisella tularensis ssp. holarctica in France

A. J. Vogler, D. N. Birdsell, J. Lee, J. Vaissaire, C. L. Doujet, M. Lapalus, D. M. Wagner, P. Keim

Biological Sciences

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Aim: To investigate the phylogeography of French Francisella tularensis ssp. holarctica isolates.Methods and Results: Canonical SNPs and MLVA were used to genotype 103 French F. tularensis ssp. holarctica isolates. We confirmed the presence of one subclade, the central and western European group (B.Br.FTNF002-00), and identified four major MLVA genotypes with no obvious geographical differentiation.Conclusions: The lack of geographical resolution among MLVA genotypes suggests rapid dispersal, convergent evolution or a combination of the two.Significance and Impact of the Study: This study expands knowledge of the phylogeography of one of the two dominant European F. tularensis ssp. holarctica subclades and illustrates the need for additional SNP discovery within this subclade.

Original language	English (US)
Pages (from-to)	177-180
Number of pages	4
Journal	Letters in Applied Microbiology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1111/j.1472-765X.2010.02977.x
State	Published - Feb 2011

Keywords

France
Francisella tularensis
MLVA
SNP
VNTR
holarctica

ASJC Scopus subject areas

Applied Microbiology and Biotechnology

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10.1111/j.1472-765X.2010.02977.x

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title = "Phylogeography of Francisella tularensis ssp. holarctica in France",

abstract = "Aim: To investigate the phylogeography of French Francisella tularensis ssp. holarctica isolates.Methods and Results: Canonical SNPs and MLVA were used to genotype 103 French F. tularensis ssp. holarctica isolates. We confirmed the presence of one subclade, the central and western European group (B.Br.FTNF002-00), and identified four major MLVA genotypes with no obvious geographical differentiation.Conclusions: The lack of geographical resolution among MLVA genotypes suggests rapid dispersal, convergent evolution or a combination of the two.Significance and Impact of the Study: This study expands knowledge of the phylogeography of one of the two dominant European F. tularensis ssp. holarctica subclades and illustrates the need for additional SNP discovery within this subclade.",

keywords = "France, Francisella tularensis, MLVA, SNP, VNTR, holarctica",

author = "Vogler, {A. J.} and Birdsell, {D. N.} and J. Lee and J. Vaissaire and Doujet, {C. L.} and M. Lapalus and Wagner, {D. M.} and P. Keim",

year = "2011",

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doi = "10.1111/j.1472-765X.2010.02977.x",

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AU - Vogler, A. J.

AU - Birdsell, D. N.

AU - Lee, J.

AU - Vaissaire, J.

AU - Doujet, C. L.

AU - Lapalus, M.

AU - Wagner, D. M.

AU - Keim, P.

PY - 2011/2

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N2 - Aim: To investigate the phylogeography of French Francisella tularensis ssp. holarctica isolates.Methods and Results: Canonical SNPs and MLVA were used to genotype 103 French F. tularensis ssp. holarctica isolates. We confirmed the presence of one subclade, the central and western European group (B.Br.FTNF002-00), and identified four major MLVA genotypes with no obvious geographical differentiation.Conclusions: The lack of geographical resolution among MLVA genotypes suggests rapid dispersal, convergent evolution or a combination of the two.Significance and Impact of the Study: This study expands knowledge of the phylogeography of one of the two dominant European F. tularensis ssp. holarctica subclades and illustrates the need for additional SNP discovery within this subclade.

AB - Aim: To investigate the phylogeography of French Francisella tularensis ssp. holarctica isolates.Methods and Results: Canonical SNPs and MLVA were used to genotype 103 French F. tularensis ssp. holarctica isolates. We confirmed the presence of one subclade, the central and western European group (B.Br.FTNF002-00), and identified four major MLVA genotypes with no obvious geographical differentiation.Conclusions: The lack of geographical resolution among MLVA genotypes suggests rapid dispersal, convergent evolution or a combination of the two.Significance and Impact of the Study: This study expands knowledge of the phylogeography of one of the two dominant European F. tularensis ssp. holarctica subclades and illustrates the need for additional SNP discovery within this subclade.

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KW - Francisella tularensis

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Phylogeography of Francisella tularensis ssp. holarctica in France

Abstract

Keywords

ASJC Scopus subject areas

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