Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

Keyphrases

• Burkholderia Pseudomallei 100%
• Pseudomallei 100%
• SNP 100%
• Population Dynamics 100%
• Dynamic Evolution 100%
• Commensal 100%
• Within-host 100%
• Dynamic Adaptation 100%
• Population Adaptation 100%
• Population Evolution 100%
• Melioidosis 66%
• Sputum 33%
• Airway 33%
• Whole Genome Sequencing 33%
• Accessory Genome 33%
• Core Genome 33%
• Mouse Model 33%
• Phylogeny 33%
• Indel 33%
• Close Relationships 33%
• Evolutionary Progression 33%
• Long-lived 33%
• Water System 33%
• Phylogenetic Tree 33%
• Environmental Isolates 33%
• Homoplasy 33%
• Reduced Mortality 33%
• Comparative Genomics 33%
• O-antigen 33%
• Evolutionary Patterns 33%
• Rare Example 33%
• Selective Pressure 33%
• Disease Severity 33%
• Symbiotic Relationship 33%
• Commensalism 33%
• Genetic Drift 33%
• Very Virulent 33%
• Commensal Relationship 33%
• Virulent Pathogens 33%
• Genetic Changes 33%
• Phenotypic Change 33%
• Capsular Polysaccharide 33%
• Human Host 33%
• Colony Morphology 33%
• Genetic Diversification 33%
• Niche Differentiation 33%
• Motility 33%
• Repeated Sampling 33%
• Non-adaptive 33%
• Home Environment 33%
• Genetic Inheritance 33%
• Microbial Adaptation 33%
• Reduced Morbidity 33%
• Therapeutic Regimen 33%
• Household Water 33%
• Two Lineages 33%
• In Situ Adaptation 33%

Immunology and Microbiology

• Infectious Agent 100%
• Burkholderia pseudomallei 100%
• Single Nucleotide Polymorphism 100%
• Lineages 100%
• Population Dynamics 100%
• Sputum 33%
• Whole Genome Sequencing 33%
• Indel Mutation 33%
• Phylogenetic Tree 33%
• Homoplasy 33%
• O Antigen 33%
• Mouse Model 33%
• Symbiotic Relationship 33%
• Commensalism 33%
• Genetic Drift 33%