Oxidative insult after ischemia/reperfusion in older adults

Tinna Traustadottir, Sean S. Davies

Research output: Chapter in Book/Report/Conference proceedingChapter


Aging is associated with significant impairment in tolerance to acute stressors such as ischemia/reperfusion and this impairment appears to contribute to the increased morbidity and mortality of older adults compared to young adults in clinical conditions associated with ischemia/reperfusion. These conditions include ischemic heart disease, stroke, and a variety of surgeries. Ischemia leads to a transition from aerobic to anaerobic metabolism with subsequent depletion of ATP, accumulation of lactate, acidosis, and loss of intracellular ion homeostasis. Reperfusion results in increased oxidative stress and calcium overload which together stimulate pathways of necrosis and apoptosis. These adverse events are exaggerated in older individuals. In particular, oxidative stress plays a central role in the age-related increase in vulnerability to ischemia/reperfusion. We outline a useful forearm ischemia/reperfusion method to assess this vulnerability in older adults and have shown that several interventions can markedly improve resistance to ischemia/reperfusion.

Original languageEnglish (US)
Title of host publicationStudies on Women's Health
PublisherHumana Press Inc.
Number of pages22
ISBN (Electronic)9781627030410
ISBN (Print)9781627030403
StatePublished - Jan 1 2013


  • Forearm ischemia/reperfusion
  • Ischemia/reperfusion
  • Ischemic preconditioning
  • Myocardial ischemia
  • Older adults
  • Oxidative insult

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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