Novel Microbiome-Based Therapeutics for Chronic Rhinosinusitis

E. K. Cope, S. V. Lynch

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

The human microbiome, i.e. the collection of microbes that live on, in and interact with the human body, is extraordinarily diverse; microbiota have been detected in every tissue of the human body interrogated to date. Resident microbiota interact extensively with immune cells and epithelia at mucosal surfaces including the airways, and chronic inflammatory and allergic respiratory disorders are associated with dysbiosis of the airway microbiome. Chronic rhinosinusitis (CRS) is a heterogeneous disease with a large socioeconomic impact, and recent studies have shown that sinus inflammation is associated with decreased sinus bacterial diversity and the concomitant enrichment of specific sinus pathogens. Here, we discuss the potential role for probiotic supplementation for CRS in light of this increasing understanding of the airway microbiome and microbial interactions with the host. We focus on the ecological significance of microbiome-based probiotic supplementation and potential interactions with the gastrointestinal tract and consider microbial administration methods for treatment of CRS.

Original languageEnglish (US)
JournalCurrent Allergy and Asthma Reports
Volume15
Issue number3
DOIs
StatePublished - Mar 2015
Externally publishedYes

Keywords

  • Airway
  • Chronic rhinosinusitis
  • CRS
  • GI-respiratory axis
  • Lactobacillus
  • Microbiome
  • Probiotic
  • Respiratory tract
  • Sinusitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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