Nonparametric Bootstrap Confidence Intervals for Variance Components Applied to Interlaboratory Comparisons

Exact confidence intervals for variance components in linear mixed models rely heavily on normal distribution assumptions. If the random effects in the model are not normally distributed, then the true coverage probabilities of these conventional intervals may be erratic. In this paper we examine the performance of nonparametric bootstrap confidence intervals based on restricted maximum likelihood (REML) estimators. Asymptotic theory suggests that these intervals will achieve the nominal coverage value as the sample size increases. Incorporating a small-sample adjustment term in the bootstrap confidence interval construction process improves the performance of these intervals for small to intermediate sample sizes. Simulation studies suggest that the bootstrap standard method (with a transformation) and the bootstrap bias-corrected and accelerated (BC _a) method produce confidence intervals that have good coverage probabilities under a variety of distribution assumptions. For an interlaboratory comparison of mercury concentration in oyster tissue, a balanced one-way random effects model is used to quantify the proportion of the variation in mercury concentration that can be attributed to the laboratories. In this application the exact confidence interval using normal distribution theory produces misleading results and inferences based on nonparametric bootstrap procedures are more appropriate.