Multivariate Calibration in Inductively Coupled Plasma Mass Spectrometry

Michael E. Ketterer, John J. Reschl, Michael J. Peters

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46 Scopus citations


To date, the existence of isobaric molecular Ion interferences resulting from the formation of species such as MO+ and MCI+ has been considered to be a significant shortcoming of inductively coupled plasma mass spectrometry (ICP/MS). In the present study, this problem has been circumvented through the use of two multivariate calibration methods, namely multiple linear regression (MLR) and principal components regression (PCR). The methods function by utilizing Information from multiple, partially selective sensors and have been applied to the nMo18O+/n+16Cd+ and nZr16O+, nMo16O+, nRu16O+/n+16Cd+, n+16In+, n+16Sn+ systems. For the former system, It was possible to determine low levels of Cd in the presence of Mo, by using either MLR or PCR; traditional univariate determinations of Cd at single isotopes were unsatisfactory. Both PCR and MLR were satisfactory for determining Cd in the presence of Zr, Mo, Ru, In, and Sn; moreover, no major advantages of PCR over MLR were observed. The ICP/MS application of MLR and PCR, as well as that of other multivariate calibration approaches not considered herein, merits further study.

Original languageEnglish (US)
Pages (from-to)2031-2040
Number of pages10
JournalAnalytical Chemistry
Issue number18
StatePublished - Sep 1989

ASJC Scopus subject areas

  • Analytical Chemistry


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