Molecular evidence of sexual transmission of ebola virus

S. E. Mate; J. R. Kugelman; T. G. Nyenswah; J. T. Ladner; M. R. Wiley; T. Cordier-Lassalle; A. Christie; G. P. Schroth; S. M. Gross; G. J. Davies-Wayne; S. A. Shinde; R. Murugan; S. B. Sieh; M. Badio; L. Fakoli; F. Taweh; E. De Wit; N. Van Doremalen; V. J. Munster; J. Pettitt; K. Prieto; B. W. Humrighouse; U. Ströher; J. W. DiClaro; L. E. Hensley; R. J. Schoepp; D. Safronetz; J. Fair; J. H. Kuhn; D. J. Blackley; A. S. Laney; D. E. Williams; T. Lo; A. Gasasira; S. T. Nichol; P. Formenty; F. N. Kateh; K. M. DeCock; F. Bolay; M. Sanchez-Lockhart; G. Palacios

doi:10.1056/NEJMoa1509773

Molecular evidence of sexual transmission of ebola virus

S. E. Mate, J. R. Kugelman, T. G. Nyenswah, J. T. Ladner, M. R. Wiley, T. Cordier-Lassalle, A. Christie, G. P. Schroth, S. M. Gross, G. J. Davies-Wayne, S. A. Shinde, R. Murugan, S. B. Sieh, M. Badio, L. Fakoli, F. Taweh, E. De Wit, N. Van Doremalen, V. J. Munster, J. PettittK. Prieto, B. W. Humrighouse, U. Ströher, J. W. DiClaro, L. E. Hensley, R. J. Schoepp, D. Safronetz, J. Fair, J. H. Kuhn, D. J. Blackley, A. S. Laney, D. E. Williams, T. Lo, A. Gasasira, S. T. Nichol, P. Formenty, F. N. Kateh, K. M. DeCock, F. Bolay, M. Sanchez-Lockhart, G. Palacios

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Abstract

A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD.

Original language	English (US)
Pages (from-to)	2448-2454
Number of pages	7
Journal	New England Journal of Medicine
Volume	373
Issue number	25
DOIs	https://doi.org/10.1056/NEJMoa1509773
State	Published - Dec 17 2015
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Mate, S. E., Kugelman, J. R., Nyenswah, T. G., Ladner, J. T., Wiley, M. R., Cordier-Lassalle, T., Christie, A., Schroth, G. P., Gross, S. M., Davies-Wayne, G. J., Shinde, S. A., Murugan, R., Sieh, S. B., Badio, M., Fakoli, L., Taweh, F., De Wit, E., Van Doremalen, N., Munster, V. J., ... Palacios, G. (2015). Molecular evidence of sexual transmission of ebola virus. New England Journal of Medicine, 373(25), 2448-2454. https://doi.org/10.1056/NEJMoa1509773

Mate, SE, Kugelman, JR, Nyenswah, TG, Ladner, JT, Wiley, MR, Cordier-Lassalle, T, Christie, A, Schroth, GP, Gross, SM, Davies-Wayne, GJ, Shinde, SA, Murugan, R, Sieh, SB, Badio, M, Fakoli, L, Taweh, F, De Wit, E, Van Doremalen, N, Munster, VJ, Pettitt, J, Prieto, K, Humrighouse, BW, Ströher, U, DiClaro, JW, Hensley, LE, Schoepp, RJ, Safronetz, D, Fair, J, Kuhn, JH, Blackley, DJ, Laney, AS, Williams, DE, Lo, T, Gasasira, A, Nichol, ST, Formenty, P, Kateh, FN, DeCock, KM, Bolay, F, Sanchez-Lockhart, M & Palacios, G 2015, 'Molecular evidence of sexual transmission of ebola virus', New England Journal of Medicine, vol. 373, no. 25, pp. 2448-2454. https://doi.org/10.1056/NEJMoa1509773

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title = "Molecular evidence of sexual transmission of ebola virus",

abstract = "A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD.",

author = "Mate, {S. E.} and Kugelman, {J. R.} and Nyenswah, {T. G.} and Ladner, {J. T.} and Wiley, {M. R.} and T. Cordier-Lassalle and A. Christie and Schroth, {G. P.} and Gross, {S. M.} and Davies-Wayne, {G. J.} and Shinde, {S. A.} and R. Murugan and Sieh, {S. B.} and M. Badio and L. Fakoli and F. Taweh and {De Wit}, E. and {Van Doremalen}, N. and Munster, {V. J.} and J. Pettitt and K. Prieto and Humrighouse, {B. W.} and U. Str{\"o}her and DiClaro, {J. W.} and Hensley, {L. E.} and Schoepp, {R. J.} and D. Safronetz and J. Fair and Kuhn, {J. H.} and Blackley, {D. J.} and Laney, {A. S.} and Williams, {D. E.} and T. Lo and A. Gasasira and Nichol, {S. T.} and P. Formenty and Kateh, {F. N.} and DeCock, {K. M.} and F. Bolay and M. Sanchez-Lockhart and G. Palacios",

year = "2015",

month = dec,

day = "17",

doi = "10.1056/NEJMoa1509773",

language = "English (US)",

volume = "373",

pages = "2448--2454",

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AU - Mate, S. E.

AU - Kugelman, J. R.

AU - Nyenswah, T. G.

AU - Ladner, J. T.

AU - Wiley, M. R.

AU - Cordier-Lassalle, T.

AU - Christie, A.

AU - Schroth, G. P.

AU - Gross, S. M.

AU - Davies-Wayne, G. J.

AU - Shinde, S. A.

AU - Murugan, R.

AU - Sieh, S. B.

AU - Badio, M.

AU - Fakoli, L.

AU - Taweh, F.

AU - De Wit, E.

AU - Van Doremalen, N.

AU - Munster, V. J.

AU - Pettitt, J.

AU - Prieto, K.

AU - Humrighouse, B. W.

AU - Ströher, U.

AU - DiClaro, J. W.

AU - Hensley, L. E.

AU - Schoepp, R. J.

AU - Safronetz, D.

AU - Fair, J.

AU - Kuhn, J. H.

AU - Blackley, D. J.

AU - Laney, A. S.

AU - Williams, D. E.

AU - Lo, T.

AU - Gasasira, A.

AU - Nichol, S. T.

AU - Formenty, P.

AU - Kateh, F. N.

AU - DeCock, K. M.

AU - Bolay, F.

AU - Sanchez-Lockhart, M.

AU - Palacios, G.

PY - 2015/12/17

Y1 - 2015/12/17

N2 - A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD.

AB - A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD.

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SP - 2448

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 25

ER -

Molecular evidence of sexual transmission of ebola virus

Abstract

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