TY - JOUR
T1 - Molecular diversity of Bacillus anthracis in Italy
AU - Fasanella, Antonio
AU - Van Ert, Matthew
AU - Altamura, Settimia A.
AU - Garofolo, Giuliano
AU - Buonavoglia, Canio
AU - Leori, Guido
AU - Huynh, Lynn
AU - Zanecki, Shaylan
AU - Keim, Paul
PY - 2005/7
Y1 - 2005/7
N2 - We used multiple-locus variable-number tandem repeat analysis (MLVA) to type 64 Bacillus anthracis isolates from outbreaks that have occurred during the past 40 years in Italy. MLVA of the 64 isolates revealed 10 unique genotypes; 9 of these genotypes and the majority of isolates (63/64) belonged to the previously described genetic cluster A1.a. Within the A1.a isolates, two previously described genotypes (G1 and G3), which differ by a single mutation in the pX01 locus, account for the majority of isolates in the country (53/63). The low diversity of B. anthracis genotypes in Italy suggests a single, dominant historical introduction, followed by limited localized differentiation.
AB - We used multiple-locus variable-number tandem repeat analysis (MLVA) to type 64 Bacillus anthracis isolates from outbreaks that have occurred during the past 40 years in Italy. MLVA of the 64 isolates revealed 10 unique genotypes; 9 of these genotypes and the majority of isolates (63/64) belonged to the previously described genetic cluster A1.a. Within the A1.a isolates, two previously described genotypes (G1 and G3), which differ by a single mutation in the pX01 locus, account for the majority of isolates in the country (53/63). The low diversity of B. anthracis genotypes in Italy suggests a single, dominant historical introduction, followed by limited localized differentiation.
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U2 - 10.1128/JCM.43.7.3398-3401.2005
DO - 10.1128/JCM.43.7.3398-3401.2005
M3 - Article
C2 - 16000465
AN - SCOPUS:22144448222
SN - 0095-1137
VL - 43
SP - 3398
EP - 3401
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 7
ER -