Metal ions are key biologically active components critical to neuronal metabolism. Biometals function as cofactors in cell respiration, enzyme function, antioxidants, oxidative stress, and neuronal signaling in synapses. Neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, dementia with Lewy bodies, Creutzfeldt-Jakob, spinocerebellar ataxia, spinal muscular atrophy, and motor neuron diseases are directly related to aging processes, but recent scientific evidence has further linked brain degeneration and neuronal death to altered levels of some biometals and mitochondrial abnormality. Development of neurodegenerative diseases rely on different factors with many layers of complexity, but with some common features including presence of protein aggregates in brain, biometals misbalance, and mitochondrial dysfunction in neurons. Here, we discuss data that support the interplay and complex implications of different biometals and role of mitochondrial dysfunctions in neurodegenerative processes.
|Original language||English (US)|
|Title of host publication||Biometals in Neurodegenerative Diseases|
|Subtitle of host publication||Mechanisms and Therapeutics|
|Number of pages||29|
|State||Published - Apr 28 2017|
- Reactive oxygen species
ASJC Scopus subject areas