Metals and Mitochondria in Neurodegeneration

Germán Plascencia-Villa, Miguel José-Yacamán, George Perry

Research output: Chapter in Book/Report/Conference proceedingChapter


Metal ions are key biologically active components critical to neuronal metabolism. Biometals function as cofactors in cell respiration, enzyme function, antioxidants, oxidative stress, and neuronal signaling in synapses. Neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, dementia with Lewy bodies, Creutzfeldt-Jakob, spinocerebellar ataxia, spinal muscular atrophy, and motor neuron diseases are directly related to aging processes, but recent scientific evidence has further linked brain degeneration and neuronal death to altered levels of some biometals and mitochondrial abnormality. Development of neurodegenerative diseases rely on different factors with many layers of complexity, but with some common features including presence of protein aggregates in brain, biometals misbalance, and mitochondrial dysfunction in neurons. Here, we discuss data that support the interplay and complex implications of different biometals and role of mitochondrial dysfunctions in neurodegenerative processes.

Original languageEnglish (US)
Title of host publicationBiometals in Neurodegenerative Diseases
Subtitle of host publicationMechanisms and Therapeutics
PublisherElsevier Inc.
Number of pages29
ISBN (Electronic)9780128045633
ISBN (Print)9780128045626
StatePublished - Apr 28 2017
Externally publishedYes


  • Aggregation
  • Alpha-synuclein
  • Alzheimer
  • Amyloid-β
  • Copper
  • Ions
  • Iron
  • Metals
  • Mitochondria
  • Neurodegeneration
  • Parkinson's
  • Reactive oxygen species
  • Zinc

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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