Market integration predicts human gut microbiome attributes across a gradient of economic development

Felicia C. Madimenos; Karen Guillemin; J. Josh Snodgrass; Lawrence S. Sugiyama; Brendan J.M. Bohannana; Keaton Stagaman; Tara J. Cepon-Robins; Melissa A. Liebert; Theresa E. Gildner; Samuel S. Urlacher

doi:10.1128/MSYSTEMS.00122-17

Market integration predicts human gut microbiome attributes across a gradient of economic development

Felicia C. Madimenos, Karen Guillemin, J. Josh Snodgrass, Lawrence S. Sugiyama, Brendan J.M. Bohannana, Keaton Stagaman, Tara J. Cepon-Robins, Melissa A. Liebert, Theresa E. Gildner, Samuel S. Urlacher

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Economic

dence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for economically related lifestyle attributes, such as ownership of specific market goods that index degree of market integration and components of traditional and nontraditional (more modern) house structure and infrastructure, and profiled the fecal microbiomes of 213 participants from a contiguous, indigenous Ecuadorian population. Despite relatively modest differences in lifestyle across the population, greater economic development correlated with significantly lower within-host diversity, higher between-host dissimilarity, and a decrease in the relative abundance of the bacterium Prevotella. These microbiome shifts were most strongly associated with more modern housing, followed by reduced ownership of traditional subsistence lifestyle-associated items.

Original language	English (US)
Article number	e00122-17
Journal	mSystems
Volume	3
Issue number	1
DOIs	https://doi.org/10.1128/MSYSTEMS.00122-17
State	Published - Feb 2018
Externally published	Yes

Keywords

Biological anthropology
Market integration
Microbial ecology
Microbiome

ASJC Scopus subject areas

Microbiology
Physiology
Biochemistry
Ecology, Evolution, Behavior and Systematics
Modeling and Simulation
Molecular Biology
Genetics
Computer Science Applications

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10.1128/MSYSTEMS.00122-17

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title = "Market integration predicts human gut microbiome attributes across a gradient of economic development",

abstract = "Economicdence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for economically related lifestyle attributes, such as ownership of specific market goods that index degree of market integration and components of traditional and nontraditional (more modern) house structure and infrastructure, and profiled the fecal microbiomes of 213 participants from a contiguous, indigenous Ecuadorian population. Despite relatively modest differences in lifestyle across the population, greater economic development correlated with significantly lower within-host diversity, higher between-host dissimilarity, and a decrease in the relative abundance of the bacterium Prevotella. These microbiome shifts were most strongly associated with more modern housing, followed by reduced ownership of traditional subsistence lifestyle-associated items.",

keywords = "Biological anthropology, Market integration, Microbial ecology, Microbiome",

author = "Madimenos, {Felicia C.} and Karen Guillemin and Snodgrass, {J. Josh} and Sugiyama, {Lawrence S.} and Bohannana, {Brendan J.M.} and Keaton Stagaman and Cepon-Robins, {Tara J.} and Liebert, {Melissa A.} and Gildner, {Theresa E.} and Urlacher, {Samuel S.}",

note = "Publisher Copyright: {\textcopyright} 2018 Stagaman et al.",

year = "2018",

month = feb,

doi = "10.1128/MSYSTEMS.00122-17",

language = "English (US)",

volume = "3",

journal = "mSystems",

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AU - Madimenos, Felicia C.

AU - Guillemin, Karen

AU - Snodgrass, J. Josh

AU - Sugiyama, Lawrence S.

AU - Bohannana, Brendan J.M.

AU - Stagaman, Keaton

AU - Cepon-Robins, Tara J.

AU - Liebert, Melissa A.

AU - Gildner, Theresa E.

AU - Urlacher, Samuel S.

PY - 2018/2

Y1 - 2018/2

N2 - Economicdence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for economically related lifestyle attributes, such as ownership of specific market goods that index degree of market integration and components of traditional and nontraditional (more modern) house structure and infrastructure, and profiled the fecal microbiomes of 213 participants from a contiguous, indigenous Ecuadorian population. Despite relatively modest differences in lifestyle across the population, greater economic development correlated with significantly lower within-host diversity, higher between-host dissimilarity, and a decrease in the relative abundance of the bacterium Prevotella. These microbiome shifts were most strongly associated with more modern housing, followed by reduced ownership of traditional subsistence lifestyle-associated items.

AB - Economicdence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for economically related lifestyle attributes, such as ownership of specific market goods that index degree of market integration and components of traditional and nontraditional (more modern) house structure and infrastructure, and profiled the fecal microbiomes of 213 participants from a contiguous, indigenous Ecuadorian population. Despite relatively modest differences in lifestyle across the population, greater economic development correlated with significantly lower within-host diversity, higher between-host dissimilarity, and a decrease in the relative abundance of the bacterium Prevotella. These microbiome shifts were most strongly associated with more modern housing, followed by reduced ownership of traditional subsistence lifestyle-associated items.

KW - Biological anthropology

KW - Market integration

KW - Microbial ecology

KW - Microbiome

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Market integration predicts human gut microbiome attributes across a gradient of economic development

Abstract

Keywords

ASJC Scopus subject areas

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