TY - JOUR
T1 - Market integration predicts human gut microbiome attributes across a gradient of economic development
AU - Madimenos, Felicia C.
AU - Guillemin, Karen
AU - Snodgrass, J. Josh
AU - Sugiyama, Lawrence S.
AU - Bohannana, Brendan J.M.
AU - Stagaman, Keaton
AU - Cepon-Robins, Tara J.
AU - Liebert, Melissa A.
AU - Gildner, Theresa E.
AU - Urlacher, Samuel S.
N1 - Funding Information:
The research reported in this publication was supported by the National Institute of General Medical Sciences of the NIH (T32GM007413 and P50GM098911), the Wenner-Gren Foundation (7970, 8476, and 8749), the National Science Foundation (BCS-1341165, BCS-0824602, BCS-0925910, and 2011109300), the Ryoichi Sasakawa Young Leaders Fellowship Fund, the Leakey Foundation, and the University of Oregon. The University of Oregon ACISS computational resources were funded by a Major Research Instrumentation grant (grant OCI-0960354) from the NSF Office of Cyber Infrastructure.
Publisher Copyright:
© 2018 Stagaman et al.
PY - 2018/2
Y1 - 2018/2
N2 - Economicdence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for economically related lifestyle attributes, such as ownership of specific market goods that index degree of market integration and components of traditional and nontraditional (more modern) house structure and infrastructure, and profiled the fecal microbiomes of 213 participants from a contiguous, indigenous Ecuadorian population. Despite relatively modest differences in lifestyle across the population, greater economic development correlated with significantly lower within-host diversity, higher between-host dissimilarity, and a decrease in the relative abundance of the bacterium Prevotella. These microbiome shifts were most strongly associated with more modern housing, followed by reduced ownership of traditional subsistence lifestyle-associated items.
AB - Economicdence of microbiome-associated diseases, such as autoimmune diseases and metabolic syndromes, but the lifestyle changes that drive alterations in the human microbiome are not known. We measured market integration as a proxy for economically related lifestyle attributes, such as ownership of specific market goods that index degree of market integration and components of traditional and nontraditional (more modern) house structure and infrastructure, and profiled the fecal microbiomes of 213 participants from a contiguous, indigenous Ecuadorian population. Despite relatively modest differences in lifestyle across the population, greater economic development correlated with significantly lower within-host diversity, higher between-host dissimilarity, and a decrease in the relative abundance of the bacterium Prevotella. These microbiome shifts were most strongly associated with more modern housing, followed by reduced ownership of traditional subsistence lifestyle-associated items.
KW - Biological anthropology
KW - Market integration
KW - Microbial ecology
KW - Microbiome
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U2 - 10.1128/MSYSTEMS.00122-17
DO - 10.1128/MSYSTEMS.00122-17
M3 - Article
AN - SCOPUS:85090861608
SN - 2379-5077
VL - 3
JO - mSystems
JF - mSystems
IS - 1
M1 - e00122-17
ER -