Lipid bilayer reorganization under extreme pH conditions

Matthew P. Goertz, Nikita Goyal, Gabriel A. Montano, Bruce C. Bunker

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Supported lipid bilayers containing phosphatidylcholine headgroups are observed to undergo reorganization from a 2D fluid, lipid bilayer assembly into an array of complex 3D structures upon exposure to extreme pH environments. These conditions induce a combination of molecular packing and electrostatic interactions that can create dynamic morphologies of highly curved lipid membrane structures. This work demonstrates that fluid, single-component lipid bilayer assemblies can create complex morphologies, a phenomenon typically only associated with lipid bilayers of mixed composition.

Original languageEnglish (US)
Pages (from-to)5481-5491
Number of pages11
Issue number9
StatePublished - May 3 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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