Investigation of DNA sensing using piezoresistive microcantilever probes

Robert L. Gunter; Rosalie Zhine; William G. Delinger; Kevin Manygoats; Ara Kooser; Timothy L. Porter

doi:10.1109/JSEN.2004.829784

Investigation of DNA sensing using piezoresistive microcantilever probes

Robert L. Gunter, Rosalie Zhine, William G. Delinger, Kevin Manygoats, Ara Kooser, Timothy L. Porter

Astronomy and Planetary Sciences

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Piezoresistive microcantilever-based sensors maybe used in a variety of sensing applications, including chemical sensing and biological sensing. In these applications, a sensing material is functionalized so as to undergo a volumetric or dimensional change upon analyte exposure. A piezoresistive microcantilever in contact with, or embedded within, the sensing material records the dimensional change as a simple resistance change in the cantilever as it is strained by the volumetric shift in the sensing layer. Here, we describe the detection of single-strand DNA by utilizing a sensing layer material consisting of thiolated single-strand DNA attached to a gold film substrate. A piezoresistive microcantilever in direct contact with this layer in solution immediately responds to the presence of the complimentary (25 base) single strand.

Original language	English (US)
Pages (from-to)	430-433
Number of pages	4
Journal	IEEE Sensors Journal
Volume	4
Issue number	4
DOIs	https://doi.org/10.1109/JSEN.2004.829784
State	Published - Aug 2004

Keywords

Cantilever
DNA
Piezoresistive
Sensor

ASJC Scopus subject areas

Instrumentation
Electrical and Electronic Engineering

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10.1109/JSEN.2004.829784

Cite this

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AU - Zhine, Rosalie

AU - Delinger, William G.

AU - Manygoats, Kevin

AU - Kooser, Ara

AU - Porter, Timothy L.

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AB - Piezoresistive microcantilever-based sensors maybe used in a variety of sensing applications, including chemical sensing and biological sensing. In these applications, a sensing material is functionalized so as to undergo a volumetric or dimensional change upon analyte exposure. A piezoresistive microcantilever in contact with, or embedded within, the sensing material records the dimensional change as a simple resistance change in the cantilever as it is strained by the volumetric shift in the sensing layer. Here, we describe the detection of single-strand DNA by utilizing a sensing layer material consisting of thiolated single-strand DNA attached to a gold film substrate. A piezoresistive microcantilever in direct contact with this layer in solution immediately responds to the presence of the complimentary (25 base) single strand.

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Investigation of DNA sensing using piezoresistive microcantilever probes

Abstract

Keywords

ASJC Scopus subject areas

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