Investigation of DNA sensing using piezoresistive microcantilever probes

Robert L. Gunter, Rosalie Zhine, William G. Delinger, Kevin Manygoats, Ara Kooser, Timothy L. Porter

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Piezoresistive microcantilever-based sensors maybe used in a variety of sensing applications, including chemical sensing and biological sensing. In these applications, a sensing material is functionalized so as to undergo a volumetric or dimensional change upon analyte exposure. A piezoresistive microcantilever in contact with, or embedded within, the sensing material records the dimensional change as a simple resistance change in the cantilever as it is strained by the volumetric shift in the sensing layer. Here, we describe the detection of single-strand DNA by utilizing a sensing layer material consisting of thiolated single-strand DNA attached to a gold film substrate. A piezoresistive microcantilever in direct contact with this layer in solution immediately responds to the presence of the complimentary (25 base) single strand.

Original languageEnglish (US)
Pages (from-to)430-433
Number of pages4
JournalIEEE Sensors Journal
Issue number4
StatePublished - Aug 2004


  • Cantilever
  • DNA
  • Piezoresistive
  • Sensor

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering


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