Interaction of silver nanoparticles with HIV-1

Jose Luis Elechiguerra, Justin L. Burt, Jose R. Morones, Alejandra Camacho-Bragado, Xiaoxia Gao, Humberto H. Lara, Miguel Jose Yacaman

Research output: Contribution to journalArticlepeer-review

1268 Scopus citations

Abstract

The interaction of nanoparticles with biomolecules and microorganisms is an expanding field of research. Within this field, an area that has been largely unexplored is the interaction of metal nanoparticles with viruses. In this work, we demonstrate that silver nanoparticles undergo a sizedependent interaction with HIV-1, with nanoparticles exclusively in the range of 1-10 nm attached to the virus. The regular spatial arrangement of the attached nanoparticles, the center-to-center distance between nanoparticles, and the fact that the exposed sulfur-bearing residues of the glycoprotein knobs would be attractive sites for nanoparticle interaction suggest that silver nanoparticles interact with the HIV-1 virus via preferential binding to the gp 120 glycoprotein knobs. Due to this interaction, silver nanoparticles inhibit the virus from binding to host cells, as demonstrated in vitro.

Original languageEnglish (US)
Article number6
JournalJournal of Nanobiotechnology
Volume3
DOIs
StatePublished - Jun 29 2005
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Applied Microbiology and Biotechnology
  • Pharmaceutical Science

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