Influence of pulmonary blood flow and O2 flux on DO2                          in avian lungs

Steven C. Hempleman; Frank L. Powell

doi:10.1016/0034-5687(86)90096-4

Influence of pulmonary blood flow and O₂ flux on D_O₂ in avian lungs

Steven C. Hempleman, Frank L. Powell

Biological Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

O₂ diffusing capacity (D_O₂) was measured in anesthetized, unidirectionally ventilated ducks during hypercapnic hypoxia. D_O₂ averaged 78.2 μmol·(min·Torr)^-1. This value increased to 97.3 μmol·(min·Torr)^-1 after correction for ventilation-perfusion inequality. D_O₂ increased when pulmonary O₂ exchange (M_O₂) and pulmonary blood flow (Ṁ) were increased by either 2,4 dinitrophenol (DNP, ca. 5 mg/kg i.v.) or temporary unilateral pulmonary artery occlusion (TUPAO). D_O₂ increased with M_O₂ 42.4 μmol·(mmol·Torr)^-1 (R=0.664), and with Q̇ 80.3 μmol·(L·Torr)^-1 (R=0.895). Since there is evidence against expansion of membrane diffusing capacity through recruitment and distention of pulmonary capillaries in avian lungs, we suggest that the close coupling of D_O₂ to Q̇ reflects a reduction of functional lung heterogeneity at higher blood flows, perhaps due to better matching of V̇ to D, or D to Q̇.

Original language	English (US)
Pages (from-to)	285-292
Number of pages	8
Journal	Respiration Physiology
Volume	63
Issue number	3
DOIs	https://doi.org/10.1016/0034-5687(86)90096-4
State	Published - Mar 1986

Keywords

2,4 dinitrophenol
Cross current
Duck
Exercise
Gas exchange
Hypoxia
Lung inhomogeneity
Oxygen diffusing capacity
Ventilation/perfusion ratio

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

Access to Document

10.1016/0034-5687(86)90096-4

Cite this

@article{fa072e4251cc4f56a325020355bd9c3a,

title = "Influence of pulmonary blood flow and O2 flux on DO2 in avian lungs",

abstract = "O2 diffusing capacity (DO2 ) was measured in anesthetized, unidirectionally ventilated ducks during hypercapnic hypoxia. DO2 averaged 78.2 μmol·(min·Torr)-1. This value increased to 97.3 μmol·(min·Torr)-1 after correction for ventilation-perfusion inequality. DO2 increased when pulmonary O2 exchange (MO2 ) and pulmonary blood flow (Ṁ) were increased by either 2,4 dinitrophenol (DNP, ca. 5 mg/kg i.v.) or temporary unilateral pulmonary artery occlusion (TUPAO). DO2 increased with MO2 42.4 μmol·(mmol·Torr)-1 (R=0.664), and with {\.Q} 80.3 μmol·(L·Torr)-1 (R=0.895). Since there is evidence against expansion of membrane diffusing capacity through recruitment and distention of pulmonary capillaries in avian lungs, we suggest that the close coupling of DO2 to {\.Q} reflects a reduction of functional lung heterogeneity at higher blood flows, perhaps due to better matching of {\.V} to D, or D to {\.Q}.",

keywords = "2,4 dinitrophenol, Cross current, Duck, Exercise, Gas exchange, Hypoxia, Lung inhomogeneity, Oxygen diffusing capacity, Ventilation/perfusion ratio",

author = "Hempleman, {Steven C.} and Powell, {Frank L.}",

year = "1986",

month = mar,

doi = "10.1016/0034-5687(86)90096-4",

language = "English (US)",

volume = "63",

pages = "285--292",

journal = "Respiration Physiology",

issn = "0034-5687",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Influence of pulmonary blood flow and O2 flux on DO2 in avian lungs

AU - Hempleman, Steven C.

AU - Powell, Frank L.

PY - 1986/3

Y1 - 1986/3

N2 - O2 diffusing capacity (DO2 ) was measured in anesthetized, unidirectionally ventilated ducks during hypercapnic hypoxia. DO2 averaged 78.2 μmol·(min·Torr)-1. This value increased to 97.3 μmol·(min·Torr)-1 after correction for ventilation-perfusion inequality. DO2 increased when pulmonary O2 exchange (MO2 ) and pulmonary blood flow (Ṁ) were increased by either 2,4 dinitrophenol (DNP, ca. 5 mg/kg i.v.) or temporary unilateral pulmonary artery occlusion (TUPAO). DO2 increased with MO2 42.4 μmol·(mmol·Torr)-1 (R=0.664), and with Q̇ 80.3 μmol·(L·Torr)-1 (R=0.895). Since there is evidence against expansion of membrane diffusing capacity through recruitment and distention of pulmonary capillaries in avian lungs, we suggest that the close coupling of DO2 to Q̇ reflects a reduction of functional lung heterogeneity at higher blood flows, perhaps due to better matching of V̇ to D, or D to Q̇.

AB - O2 diffusing capacity (DO2 ) was measured in anesthetized, unidirectionally ventilated ducks during hypercapnic hypoxia. DO2 averaged 78.2 μmol·(min·Torr)-1. This value increased to 97.3 μmol·(min·Torr)-1 after correction for ventilation-perfusion inequality. DO2 increased when pulmonary O2 exchange (MO2 ) and pulmonary blood flow (Ṁ) were increased by either 2,4 dinitrophenol (DNP, ca. 5 mg/kg i.v.) or temporary unilateral pulmonary artery occlusion (TUPAO). DO2 increased with MO2 42.4 μmol·(mmol·Torr)-1 (R=0.664), and with Q̇ 80.3 μmol·(L·Torr)-1 (R=0.895). Since there is evidence against expansion of membrane diffusing capacity through recruitment and distention of pulmonary capillaries in avian lungs, we suggest that the close coupling of DO2 to Q̇ reflects a reduction of functional lung heterogeneity at higher blood flows, perhaps due to better matching of V̇ to D, or D to Q̇.

KW - 2,4 dinitrophenol

KW - Cross current

KW - Duck

KW - Exercise

KW - Gas exchange

KW - Hypoxia

KW - Lung inhomogeneity

KW - Oxygen diffusing capacity

KW - Ventilation/perfusion ratio

UR - http://www.scopus.com/inward/record.url?scp=0022602725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022602725&partnerID=8YFLogxK

U2 - 10.1016/0034-5687(86)90096-4

DO - 10.1016/0034-5687(86)90096-4

M3 - Article

C2 - 3961300

AN - SCOPUS:0022602725

SN - 0034-5687

VL - 63

SP - 285

EP - 292

JO - Respiration Physiology

JF - Respiration Physiology

IS - 3

ER -