TY - JOUR
T1 - Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors
T2 - A randomized controlled trial
AU - Winters-Stone, K. M.
AU - Dobek, J.
AU - Nail, L. M.
AU - Bennett, J. A.
AU - Leo, M. C.
AU - Torgrimson-Ojerio, B.
AU - Luoh, S. W.
AU - Schwartz, A.
N1 - Funding Information:
Funding was provided by an American Cancer Society Research Scholar Grant (RSGPB-06-092-01-CPPB). We thank the Oregon State Cancer Registry for their assistance with recruitment; Thera-band, Inc. for providing elastic exercise bands; and our research assistants, exercise trainers, and participants.
PY - 2013/5
Y1 - 2013/5
N2 - Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year. Introduction: Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause. Methods: We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter). Results: There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck - POWIR, 0.004 ± 0.093 g/cm2 vs. FLEX, -0.010 ± 0.089 g/cm2; p < 0.01; spine - POWIR, -0.003 ± 0.114 g/cm2 vs. FLEX, -0.020 ± 0.110 g/cm 2; p = 0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; p < 0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (p < 0.03). Conclusion: Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.
AB - Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year. Introduction: Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause. Methods: We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter). Results: There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck - POWIR, 0.004 ± 0.093 g/cm2 vs. FLEX, -0.010 ± 0.089 g/cm2; p < 0.01; spine - POWIR, -0.003 ± 0.114 g/cm2 vs. FLEX, -0.020 ± 0.110 g/cm 2; p = 0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; p < 0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (p < 0.03). Conclusion: Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.
KW - Chemotherapy
KW - Neoplasm
KW - Obesity
KW - Osteoporosis
KW - Physical activity
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U2 - 10.1007/s00198-012-2143-2
DO - 10.1007/s00198-012-2143-2
M3 - Article
C2 - 22996743
AN - SCOPUS:84881511614
SN - 0937-941X
VL - 24
SP - 1637
EP - 1646
JO - Osteoporosis International
JF - Osteoporosis International
IS - 5
ER -