Historical distribution and molecular diversity of bacillus anthracis, Kazakhstan

Alim M. Aikembayev; Larissa Lukhnova; Gulnara Temiraliyeva; Tatyana Meka-Mechenko; Yerlan Pazylov; Sarkis Zakaryan; Georgiy Denissov; W. Ryan Easterday; Matthew N. Van Ert; Paul Keim; Stephen C. Francesconi; Jason K. Blackburn; Martin Hugh-Jones; Ted Hadfield

doi:10.3201/eid1605.091427

Historical distribution and molecular diversity of bacillus anthracis, Kazakhstan

Alim M. Aikembayev, Larissa Lukhnova, Gulnara Temiraliyeva, Tatyana Meka-Mechenko, Yerlan Pazylov, Sarkis Zakaryan, Georgiy Denissov, W. Ryan Easterday, Matthew N. Van Ert, Paul Keim, Stephen C. Francesconi, Jason K. Blackburn, Martin Hugh-Jones, Ted Hadfield

Biological Sciences

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

To map the distribution of anthrax outbreaks and strain subtypes in Kazakhstan during 1937-2005, we combined geographic information system technology and genetic analysis by using archived cultures and data. Biochemical and genetic tests confi rmed the identity of 93 archived cultures in the Kazakhstan National Culture Collection as Bacillus anthracis. Multilocus variable number tandem repeat analysis genotyping identifi ed 12 genotypes. Cluster analysis comparing these genotypes with previously published genotypes indicated that most (n = 78) isolates belonged to the previously described A1.a genetic cluster, 6 isolates belonged to the A3.b cluster, and 2 belonged to the A4 cluster. Two genotypes in the collection appeared to represent novel genetic sublineages; 1 of these isolates was from Krygystan. Our data provide a description of the historical, geographic, and genetic diversity of B. anthracis in this Central Asian region.

Original language	English (US)
Pages (from-to)	789-796
Number of pages	8
Journal	Emerging infectious diseases
Volume	16
Issue number	5
DOIs	https://doi.org/10.3201/eid1605.091427
State	Published - May 2010

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Aikembayev, A. M., Lukhnova, L., Temiraliyeva, G., Meka-Mechenko, T., Pazylov, Y., Zakaryan, S., Denissov, G., Ryan Easterday, W., Van Ert, M. N., Keim, P., Francesconi, S. C., Blackburn, J. K., Hugh-Jones, M., & Hadfield, T. (2010). Historical distribution and molecular diversity of bacillus anthracis, Kazakhstan. Emerging infectious diseases, 16(5), 789-796. https://doi.org/10.3201/eid1605.091427

Aikembayev, AM, Lukhnova, L, Temiraliyeva, G, Meka-Mechenko, T, Pazylov, Y, Zakaryan, S, Denissov, G, Ryan Easterday, W, Van Ert, MN, Keim, P, Francesconi, SC, Blackburn, JK, Hugh-Jones, M & Hadfield, T 2010, 'Historical distribution and molecular diversity of bacillus anthracis, Kazakhstan', Emerging infectious diseases, vol. 16, no. 5, pp. 789-796. https://doi.org/10.3201/eid1605.091427

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abstract = "To map the distribution of anthrax outbreaks and strain subtypes in Kazakhstan during 1937-2005, we combined geographic information system technology and genetic analysis by using archived cultures and data. Biochemical and genetic tests confi rmed the identity of 93 archived cultures in the Kazakhstan National Culture Collection as Bacillus anthracis. Multilocus variable number tandem repeat analysis genotyping identifi ed 12 genotypes. Cluster analysis comparing these genotypes with previously published genotypes indicated that most (n = 78) isolates belonged to the previously described A1.a genetic cluster, 6 isolates belonged to the A3.b cluster, and 2 belonged to the A4 cluster. Two genotypes in the collection appeared to represent novel genetic sublineages; 1 of these isolates was from Krygystan. Our data provide a description of the historical, geographic, and genetic diversity of B. anthracis in this Central Asian region.",

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AU - Pazylov, Yerlan

AU - Zakaryan, Sarkis

AU - Denissov, Georgiy

AU - Ryan Easterday, W.

AU - Van Ert, Matthew N.

AU - Keim, Paul

AU - Francesconi, Stephen C.

AU - Blackburn, Jason K.

AU - Hugh-Jones, Martin

AU - Hadfield, Ted

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Historical distribution and molecular diversity of bacillus anthracis, Kazakhstan

Abstract

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