High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux

Rungtip Chuanchuen; Rox Ann R. Karkhoff-Schweizer; Herbert P. Schweizer

doi:10.1067/mic.2003.11

High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux

Rungtip Chuanchuen, Rox Ann R. Karkhoff-Schweizer, Herbert P. Schweizer

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 μg/mL) triclosan resistance in P aeruginosa was assessed. Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 μg/mL is solely attributable to the expression of efflux pumps.

Original language	English (US)
Pages (from-to)	124-127
Number of pages	4
Journal	American Journal of Infection Control
Volume	31
Issue number	2
DOIs	https://doi.org/10.1067/mic.2003.11
State	Published - Apr 2003
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Health Policy
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1067/mic.2003.11

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title = "High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux",

abstract = "Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 μg/mL) triclosan resistance in P aeruginosa was assessed. Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 μg/mL is solely attributable to the expression of efflux pumps.",

author = "Rungtip Chuanchuen and Karkhoff-Schweizer, \{Rox Ann R.\} and Schweizer, \{Herbert P.\}",

note = "Funding Information: Supported by NIH grant GM56685. The triclosan used in this study was an experimental sample that was provided free of charge by KIC Chemicals, Armonk, NY. Genechips (Affymetrix, Santa Clara, Calif) were subsidized by Cystic Fibrosis Foundation Therapeutics (Arlington, Va). ",

year = "2003",

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doi = "10.1067/mic.2003.11",

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AU - Chuanchuen, Rungtip

AU - Karkhoff-Schweizer, Rox Ann R.

AU - Schweizer, Herbert P.

N1 - Funding Information: Supported by NIH grant GM56685. The triclosan used in this study was an experimental sample that was provided free of charge by KIC Chemicals, Armonk, NY. Genechips (Affymetrix, Santa Clara, Calif) were subsidized by Cystic Fibrosis Foundation Therapeutics (Arlington, Va).

PY - 2003/4

Y1 - 2003/4

N2 - Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 μg/mL) triclosan resistance in P aeruginosa was assessed. Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 μg/mL is solely attributable to the expression of efflux pumps.

AB - Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 μg/mL) triclosan resistance in P aeruginosa was assessed. Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 μg/mL is solely attributable to the expression of efflux pumps.

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JO - American Journal of Infection Control

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High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux

Abstract

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