High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux

Rungtip Chuanchuen, Rox Ann R. Karkhoff-Schweizer, Herbert P. Schweizer

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 μg/mL) triclosan resistance in P aeruginosa was assessed. Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 μg/mL is solely attributable to the expression of efflux pumps.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalAmerican Journal of Infection Control
Volume31
Issue number2
DOIs
StatePublished - Apr 2003
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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