Background: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. Methods: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (> 1000 μg/mL) triclosan resistance in P aeruginosa was assessed. Results: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1000 μg/mL is solely attributable to the expression of efflux pumps.
ASJC Scopus subject areas
- Health Policy
- Public Health, Environmental and Occupational Health
- Infectious Diseases