TY - JOUR
T1 - High Genetic Diversity of Histoplasma in the Amazon Basin, 2006-2017
AU - Ly, Tani
AU - de Melo Teixeira, Marcus
AU - Jofre, Gaston I.
AU - Blanchet, Denis
AU - MacDonald, Sigrid
AU - Alvarado, Primavera
AU - Marques da Silva, Silvia Helena
AU - Sepúlveda, Victoria E.
AU - Zeb, Qandeel
AU - Vreden, Stephen
AU - Adenis, Antoine
AU - Yegres, Francisco
AU - Demar, Magalie
AU - Buitrago, Maria José Serna
AU - Barker, Bridget M.
AU - Nacher, Mathieu
AU - Matute, Daniel R.
N1 - Publisher Copyright:
© 2025, Centers for Disease Control and Prevention (CDC). All rigths reserved.
PY - 2025/6
Y1 - 2025/6
N2 - Histoplasmosis is one of the most common pulmonary mycosis diseases in the world. Genome sequencing has revealed that Histoplasma, the cause of histoplasmosis, is composed of several phylogenetic species. The genetic diversity of the pathogen remains largely unknown, especially in the tropics. We sequenced the genomes of 91 Histoplasma isolates from the Amazon basin of South America and used phylogenomics and population genetic evidence to measure the genetic variation of the genus in South America. We report a previously unidentified clade of Histoplasma endemic to the Amazon basin. The lineage is widespread across the continent and contains 5 lineages that are sufficiently differentiated to be considered phylogenetic species. We found the geographic range of those lineages is largely but not completely overlapping. Finally, we found that the patient median age and sex ratio differs among species, suggesting differences in the epidemiology of histoplasmosis caused by each Histoplasma lineage.
AB - Histoplasmosis is one of the most common pulmonary mycosis diseases in the world. Genome sequencing has revealed that Histoplasma, the cause of histoplasmosis, is composed of several phylogenetic species. The genetic diversity of the pathogen remains largely unknown, especially in the tropics. We sequenced the genomes of 91 Histoplasma isolates from the Amazon basin of South America and used phylogenomics and population genetic evidence to measure the genetic variation of the genus in South America. We report a previously unidentified clade of Histoplasma endemic to the Amazon basin. The lineage is widespread across the continent and contains 5 lineages that are sufficiently differentiated to be considered phylogenetic species. We found the geographic range of those lineages is largely but not completely overlapping. Finally, we found that the patient median age and sex ratio differs among species, suggesting differences in the epidemiology of histoplasmosis caused by each Histoplasma lineage.
UR - https://www.scopus.com/pages/publications/105007129100
UR - https://www.scopus.com/pages/publications/105007129100#tab=citedBy
U2 - 10.3201/eid3106.241386
DO - 10.3201/eid3106.241386
M3 - Article
C2 - 40439432
AN - SCOPUS:105007129100
SN - 1080-6040
VL - 31
SP - 1169
EP - 1177
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 6
ER -