Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

M. P. Dempsey; M. Dobson; C. Zhang; M. Zhang; C. Lion; C. B. Gutiérrez-Martín; P. C. Iwen; P. D. Fey; M. E. Olson; D. Niemeyer; S. Francesconi; R. Crawford; M. Stanley; J. Rhodes; D. M. Wagner; A. J. Vogler; D. Birdsell; P. Keim; A. Johansson; S. H. Hinrichs; A. K. Benson

doi:10.1128/AEM.00646-07

Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

M. P. Dempsey
, M. Dobson
, C. Zhang
, M. Zhang
, C. Lion
, C. B. Gutiérrez-Martín
, P. C. Iwen
, P. D. Fey
, M. E. Olson
, D. Niemeyer
, S. Francesconi
, R. Crawford
, M. Stanley
, J. Rhodes
, D. M. Wagner
, A. J. Vogler
, D. Birdsell
, P. Keim
, A. Johansson
, S. H. Hinrichs

A. K. Benson

Biological Sciences

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.

Original language	English (US)
Pages (from-to)	7465-7470
Number of pages	6
Journal	Applied and Environmental Microbiology
Volume	73
Issue number	22
DOIs	https://doi.org/10.1128/AEM.00646-07
State	Published - Nov 2007

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology
Ecology

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Dempsey, M. P., Dobson, M., Zhang, C., Zhang, M., Lion, C., Gutiérrez-Martín, C. B., Iwen, P. C., Fey, P. D., Olson, M. E., Niemeyer, D., Francesconi, S., Crawford, R., Stanley, M., Rhodes, J., Wagner, D. M., Vogler, A. J., Birdsell, D., Keim, P., Johansson, A., ... Benson, A. K. (2007). Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula. Applied and Environmental Microbiology, 73(22), 7465-7470. https://doi.org/10.1128/AEM.00646-07

Dempsey, MP, Dobson, M, Zhang, C, Zhang, M, Lion, C, Gutiérrez-Martín, CB, Iwen, PC, Fey, PD, Olson, ME, Niemeyer, D, Francesconi, S, Crawford, R, Stanley, M, Rhodes, J, Wagner, DM, Vogler, AJ, Birdsell, D, Keim, P, Johansson, A, Hinrichs, SH & Benson, AK 2007, 'Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula', Applied and Environmental Microbiology, vol. 73, no. 22, pp. 7465-7470. https://doi.org/10.1128/AEM.00646-07

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title = "Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula",

abstract = "Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.",

author = "Dempsey, \{M. P.\} and M. Dobson and C. Zhang and M. Zhang and C. Lion and Guti{\'e}rrez-Mart{\'i}n, \{C. B.\} and Iwen, \{P. C.\} and Fey, \{P. D.\} and Olson, \{M. E.\} and D. Niemeyer and S. Francesconi and R. Crawford and M. Stanley and J. Rhodes and Wagner, \{D. M.\} and Vogler, \{A. J.\} and D. Birdsell and P. Keim and A. Johansson and Hinrichs, \{S. H.\} and Benson, \{A. K.\}",

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AU - Dempsey, M. P.

AU - Dobson, M.

AU - Zhang, C.

AU - Zhang, M.

AU - Lion, C.

AU - Gutiérrez-Martín, C. B.

AU - Iwen, P. C.

AU - Fey, P. D.

AU - Olson, M. E.

AU - Niemeyer, D.

AU - Francesconi, S.

AU - Crawford, R.

AU - Stanley, M.

AU - Rhodes, J.

AU - Wagner, D. M.

AU - Vogler, A. J.

AU - Birdsell, D.

AU - Keim, P.

AU - Johansson, A.

AU - Hinrichs, S. H.

AU - Benson, A. K.

PY - 2007/11

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AB - Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.

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JF - Applied and Environmental Microbiology

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ER -

Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

Abstract

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