Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

M. P. Dempsey; M. Dobson; C. Zhang; M. Zhang; C. Lion; C. B. Gutiérrez-Martín; P. C. Iwen; P. D. Fey; M. E. Olson; D. Niemeyer; S. Francesconi; R. Crawford; M. Stanley; J. Rhodes; D. M. Wagner; A. J. Vogler; D. Birdsell; P. Keim; A. Johansson; S. H. Hinrichs; A. K. Benson

doi:10.1128/AEM.00646-07

Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

M. P. Dempsey, M. Dobson, C. Zhang, M. Zhang, C. Lion, C. B. Gutiérrez-Martín, P. C. Iwen, P. D. Fey, M. E. Olson, D. Niemeyer, S. Francesconi, R. Crawford, M. Stanley, J. Rhodes, D. M. Wagner, A. J. Vogler, D. Birdsell, P. Keim, A. Johansson, S. H. HinrichsA. K. Benson

Biological Sciences

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.

Original language	English (US)
Pages (from-to)	7465-7470
Number of pages	6
Journal	Applied and Environmental Microbiology
Volume	73
Issue number	22
DOIs	https://doi.org/10.1128/AEM.00646-07
State	Published - Nov 2007

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology
Ecology

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Dempsey, M. P., Dobson, M., Zhang, C., Zhang, M., Lion, C., Gutiérrez-Martín, C. B., Iwen, P. C., Fey, P. D., Olson, M. E., Niemeyer, D., Francesconi, S., Crawford, R., Stanley, M., Rhodes, J., Wagner, D. M., Vogler, A. J., Birdsell, D., Keim, P., Johansson, A., ... Benson, A. K. (2007). Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula. Applied and Environmental Microbiology, 73(22), 7465-7470. https://doi.org/10.1128/AEM.00646-07

Dempsey, MP, Dobson, M, Zhang, C, Zhang, M, Lion, C, Gutiérrez-Martín, CB, Iwen, PC, Fey, PD, Olson, ME, Niemeyer, D, Francesconi, S, Crawford, R, Stanley, M, Rhodes, J, Wagner, DM, Vogler, AJ, Birdsell, D, Keim, P, Johansson, A, Hinrichs, SH & Benson, AK 2007, 'Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula', Applied and Environmental Microbiology, vol. 73, no. 22, pp. 7465-7470. https://doi.org/10.1128/AEM.00646-07

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abstract = "Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.",

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AU - Zhang, M.

AU - Lion, C.

AU - Gutiérrez-Martín, C. B.

AU - Iwen, P. C.

AU - Fey, P. D.

AU - Olson, M. E.

AU - Niemeyer, D.

AU - Francesconi, S.

AU - Crawford, R.

AU - Stanley, M.

AU - Rhodes, J.

AU - Wagner, D. M.

AU - Vogler, A. J.

AU - Birdsell, D.

AU - Keim, P.

AU - Johansson, A.

AU - Hinrichs, S. H.

AU - Benson, A. K.

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AB - Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.

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Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

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