Genetically Engineered Elastomeric Polymer Network through Protein Zipper Assembly

Hossein Fazelinia, Eva Rose M. Balog, Anil Desireddy, Saumen Chakraborty, Chris J. Sheehan, Charlie E.M. Strauss, Jennifer S. Martinez

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The rich palette of chemical and functional diversity found within peptides has driven the recent interest in bottom-up assembly of soft polypeptide-based materials. Herein, we describe the creation of a novel helix-elastin like polymer or HELP. HELP marries the specificity of coiled-coil interactions with the elasticity and stimuli-responsive behavior of elastin, a class of polymers with extraordinary elasticity. We used Rosetta to computationally design highly specific protein helical zippers to connect short elastin segments. The programmed pairing between the helical blocks of two individual chains produced a genetically encoded material that, when deposited on a substrate, formed a flexible and porous 2D planar network with controllable porosity that responds dynamically upon application of stimuli.

Original languageEnglish (US)
Pages (from-to)5008-5012
Number of pages5
JournalChemistrySelect
Volume2
Issue number18
DOIs
StatePublished - Jun 21 2017
Externally publishedYes

Keywords

  • Elastin like polymer
  • Helical zipper
  • Protein design
  • Self-assembly
  • Stimuli responsive polymer

ASJC Scopus subject areas

  • Chemistry(all)

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